SR9243
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MedKoo CAT#: 407152

CAS#: 1613028-81-1

Description: SR9243 is a potent and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. SR9243 induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes. In cancer cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression. SR9243 induced apoptosis in tumors without inducing weight loss, hepatotoxicity, or inflammation. Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 1950
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 2950
Size
Price

50mg
USD 250
500mg
USD 1250
5g
Ask price

SR9243, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407152
Name: SR9243
CAS#: 1613028-81-1
Chemical Formula: C31H32BrNO4S2
Exact Mass: 625.09561
Molecular Weight: 626.62
Elemental Analysis: C, 59.42; H, 5.15; Br, 12.75; N, 2.24; O, 10.21; S, 10.23


Synonym: SR9243; SR-9243; SR 9243.

IUPAC/Chemical Name: N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide

SMILES Code: O=S(C1=C(C)C=C(C)C=C1C)(N(CCC2=CC=CC(Br)=C2)CC3=CC=C(C4=CC=CC(S(=O)(C)=O)=C4)C=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: New Compound Targets Warburg Effect. Cancer Discov. 2015 Sep;5(9):898. doi:
10.1158/2159-8290.CD-NB2015-108. Epub 2015 Jul 24. PubMed PMID: 26209538.

2: Flaveny CA, Griffett K, El-Gendy Bel-D, Kazantzis M, Sengupta M, Amelio AL,
Chatterjee A, Walker J, Solt LA, Kamenecka TM, Burris TP. Broad Anti-tumor
Activity of a Small Molecule that Selectively Targets the Warburg Effect and
Lipogenesis. Cancer Cell. 2015 Jul 13;28(1):42-56. doi:
10.1016/j.ccell.2015.05.007. Epub 2015 Jun 25. PubMed PMID: 26120082.