WHI-P131
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407145

CAS#: 202475-60-3

Description: WHI-P131, also known as Janex 1, is a potent and selective Janus kinase 3 inhibitor with an IC50 value of 78 µM. WHI-P131 inhibits human glioblastoma cell adhesion and invasion. WHI-P131 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 1950
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 2950
Size
Price

50mg
USD 250
500mg
USD 1250
5g
Ask price

WHI-P131, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407145
Name: WHI-P131
CAS#: 202475-60-3
Chemical Formula: C16H15N3O3
Exact Mass: 297.11134
Molecular Weight: 297.31
Elemental Analysis: C, 64.64; H, 5.09; N, 14.13; O, 16.14


Synonym: WHI-P131, WHI P-131, WHI P131, Janex 1

IUPAC/Chemical Name: 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

InChi Key: HOZUXBLMYUPGPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)

SMILES Code: OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1


Technical Data

Appearance:
White to off-white crystalline powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Uckun FM, Dibirdik I, Qazi S. Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase. Arzneimittelforschung. 2010;60(4):218-25. doi: 10.1055/s-0031-1296276. PubMed PMID: 20486473.

2: Mitiushova EV, Aksenov ND, Marakhova II. [Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. Tsitologiia. 2010;52(2):184-90. Russian. PubMed PMID: 20352702.

3: Linwong W, Hirasawa N, Aoyama S, Hamada H, Saito T, Ohuchi K. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br J Pharmacol. 2005 Jul;145(6):818-28. PubMed PMID: 15852029; PubMed Central PMCID: PMC1576194.

4: Uckun FM, Roers BA, Waurzyniak B, Liu XP, Cetkovic-Cvrlje M. Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model. Blood. 2002 Jun 1;99(11):4192-9. PubMed PMID: 12010825.

5: Malavija R, Chen CL, Liu XP, Uckun FM. In vivo pharmacokinetics and anti-anaphylactic activity of the novel mast cell inhibitor 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131). Am J Ther. 2001 Jan-Feb;8(1):35-9. PubMed PMID: 11304656.

6: Uckun FM, Ek O, Liu XP, Chen CL. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. PubMed PMID: 10537365.

7: Chen CL, Malaviya R, Chen H, Liu XP, Uckun FM. Quantitative high-performance liquid chromatographic method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P131). J Chromatogr B Biomed Sci Appl. 1999 Apr 30;727(1-2):205-12. PubMed PMID: 10360439.

8: Narla RK, Liu XP, Klis D, Uckun FM. Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154). Clin Cancer Res. 1998 Oct;4(10):2463-71. PubMed PMID: 9796979.