ABE171

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522374

CAS#: 426268-06-6

Description: ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrophil influx and activation with an ED(50) in the range of 3 mg/kg. NVP-ABE171 shows activity both in vitro on human inflammatory cells and in vivo in animal models of lung inflammation.

Chemical Structure

ABE171

CAS# 426268-06-6

Instruction

Theoretical Analysis

MedKoo Cat#: 522374
Name: ABE171
CAS#: 426268-06-6
Chemical Formula: C21H12N4O3
Exact Mass: 368.09
Molecular Weight: 368.350
Elemental Analysis: C, 68.48; H, 3.28; N, 15.21; O, 13.03

Price and Availability

Size	Price	Availability	Quantity
10mg	USD -2
25mg	USD -2
50mg	USD -2
100mg	USD -2
200mg	USD -2
500mg	USD -2
1g	USD -1
2g	USD -1
5g	USD -1
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ABE171; ABE-171; ABE 171; NVP-ABE171; NVP-ABE-171; NVP-ABE 171.

IUPAC/Chemical Name: 4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyridin-6-yl)benzoic acid

InChi Key: IALXIRPKVRUJQO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H12N4O3/c26-21(27)13-5-3-12(4-6-13)17-10-14-2-1-9-22-19(14)20(23-17)15-7-8-16-18(11-15)25-28-24-16/h1-11H,(H,26,27)

SMILES Code: O=C(O)C1=CC=C(C2=NC(C3=CC4=NON=C4C=C3)=C5N=CC=CC5=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 368.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Powers GL, Hammer KD, Domenech M, Frantskevich K, Malinowski RL, Bushman W,
Beebe DJ, Marker PC. Phosphodiesterase 4D inhibitors limit prostate cancer growth
potential. Mol Cancer Res. 2015 Jan;13(1):149-60. doi:
10.1158/1541-7786.MCR-14-0110. Epub 2014 Aug 22. PubMed PMID: 25149359; PubMed
Central PMCID: PMC4312503.

2: Tigani B, Cannet C, Zurbrugg S, Schaeublin E, Mazzoni L, Fozard JR, Beckmann
N. Resolution of the oedema associated with allergic pulmonary inflammation in
rats assessed noninvasively by magnetic resonance imaging. Br J Pharmacol. 2003
Sep;140(2):239-46. Epub 2003 Aug 18. PubMed PMID: 12970099; PubMed Central PMCID:
PMC1574026.

3: Trifilieff A, Wyss D, Walker C, Mazzoni L, Hersperger R. Pharmacological
profile of a novel phosphodiesterase 4 inhibitor,
4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid
(NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities.
J Pharmacol Exp Ther. 2002 Apr;301(1):241-8. PubMed PMID: 11907180.

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