Cycloastragenol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 600127

CAS#: 84605-18-5

Description: Cycloastragenol is a molecule isolated from various species of Astragalus that is purported to have telomerase activation activity. A single in vitro study done in 2009 led to claims that cycloastragenol may activate telomerase, leading to controversial claims for its role in reducing the effects of aging.


Price and Availability

Size
Price

100mg
USD 250
1g
USD 1450
Size
Price

200mg
USD 450
Size
Price

500mg
USD 950

Cycloastragenol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 600127
Name: Cycloastragenol
CAS#: 84605-18-5
Chemical Formula: C30H50O5
Exact Mass: 490.36582
Molecular Weight: 490.72
Elemental Analysis: C, 73.43; H, 10.27; O, 16.30


Synonym: Cyclogalegigenin; Astramembrangenin

IUPAC/Chemical Name: (3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

InChi Key: WENNXORDXYGDTP-WUAHQTHMSA-N

InChi Code: InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29+,30+/m0/s1

SMILES Code: CC1(C)[C@@H](O)CC[C@]2(C3)[C@@]43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6C(C)(O)C)[C@@H](O)C[C@](C)5[C@]4([H])C[C@H](O)[C@@]12[H]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wang S, Zhai C, Liu Q, Wang X, Ren Z, Zhang Y, Zhang Y, Wu Q, Sun S, Li S, Qiao Y. Cycloastragenol, a triterpene aglycone derived from Radix astragali, suppresses the accumulation of cytoplasmic lipid droplet in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2014 Jul 18;450(1):306-11. doi: 10.1016/j.bbrc.2014.05.117. Epub 2014 Jun 2. PubMed PMID: 24942874.

2: Feng LM, Lin XH, Huang FX, Cao J, Qiao X, Guo DA, Ye M. Smith degradation, an efficient method for the preparation of cycloastragenol from astragaloside IV. Fitoterapia. 2014 Jun;95:42-50. doi: 10.1016/j.fitote.2014.02.014. Epub 2014 Mar 5. PubMed PMID: 24613799.

3: Szabo NJ. Dietary safety of cycloastragenol from Astragalus spp.: subchronic toxicity and genotoxicity studies. Food Chem Toxicol. 2014 Feb;64:322-34. doi: 10.1016/j.fct.2013.11.041. Epub 2013 Dec 4. PubMed PMID: 24316212.

4: Kuban M, Öngen G, Khan IA, Bedir E. Microbial transformation of cycloastragenol. Phytochemistry. 2013 Apr;88:99-104. doi: 10.1016/j.phytochem.2012.12.007. Epub 2013 Jan 26. PubMed PMID: 23357596.

5: Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH. Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med. 2012 Jan;78(2):115-21. doi: 10.1055/s-0031-1280346. Epub 2011 Nov 14. PubMed PMID: 22083896.

6: Zhu J, Lee S, Ho MK, Hu Y, Pang H, Ip FC, Chin AC, Harley CB, Ip NY, Wong YH. In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab Pharmacokinet. 2010;25(5):477-86. Epub 2010 Sep 22. PubMed PMID: 20877137.

7: Kuban M, Ongen G, Bedir E. Biotransformation of cycloastragenol by Cunninghamella blakesleeana NRRL 1369 resulting in a novel framework. Org Lett. 2010 Oct 1;12(19):4252-5. doi: 10.1021/ol101642a. PubMed PMID: 20809612.