WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510265
Description: ZLN005 is a PGC-1α Transcriptional Regulator, which shoed some beneficialfEffects on diabetic db/db mice. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. Hyperglycemia and dyslipidemia also were ameliorated after treatment with ZLN005. Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.
MedKoo Cat#: 510265
Chemical Formula: C17H18N2
Exact Mass: 250.147
Molecular Weight: 250.33822
Elemental Analysis: C, 81.56; H, 7.25; N, 11.19
Synonym: ZLN005; ZLN-005; ZLN 005.
IUPAC/Chemical Name: 2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazole
InChi Key: LQUNNCQSFFKSSK-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
SMILES Code: CC(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)(C)C
1: Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307. doi: 10.2337/db12-0703. Epub 2012 Dec 18. PubMed PMID: 23250358; PubMed Central PMCID: PMC3609556.