WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510290
Description: XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
MedKoo Cat#: 510290
Chemical Formula: C18H17F3N2O3
Exact Mass: 366.11913
Molecular Weight: 366.33
Elemental Analysis: C, 59.02; H, 4.68; F, 15.56; N, 7.65; O, 13.10
Synonym: XEN445; XEN 445; XEN-445
IUPAC/Chemical Name: (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
InChi Key: NBGRERFNOKZQLO-AWEZNQCLSA-N
InChi Code: InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
SMILES Code: O=C(O)C1=CC(C(F)(F)F)=CC=C1N2C[C@@H](OCC3=NC=CC=C3)CC2
1: Sun S, Dean R, Jia Q, Zenova A, Zhong J, Grayson C, Xie C, Lindgren A, Samra P, Sojo L, van Heek M, Lin L, Percival D, Fu JM, Winther MD, Zhang Z. Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34. doi: 10.1016/j.bmc.2013.10.023. Epub 2013 Oct 28. PubMed PMID: 24211162.
2: Kim YT, Lee HJ, Lee SW, Kim JY, Wi HC, Park SJ, Bae SJ, Kang HJ. Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation. Xenotransplantation. 2008 Feb;15(1):27-35. doi: 10.1111/j.1399-3089.2008.00445.x. PubMed PMID: 18333911.