NSI-189

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510270

CAS#: 1270138-40-3

Description: NSI-189 is currently discontinued.


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NSI-189 is discontinued.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 510270
Name: NSI-189
CAS#: 1270138-40-3
Chemical Formula: C22H30N4O
Exact Mass: 366.24196
Molecular Weight: 366.4998
Elemental Analysis: C, 72.10; H, 8.25; N, 15.29; O, 4.37


Synonym: NSI-189; NSI 189; NSI189.

IUPAC/Chemical Name: (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone

InChi Key: DYTOQURYRYYNOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)

SMILES Code: O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC=CN=C3NCCC(C)C


Technical Data

Appearance:
white to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  


References

1: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1372-80. doi:
10.1038/mp.2015.178. PubMed PMID: 26643541; PubMed Central PMCID: PMC5030464.

2: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1483-4. doi:
10.1038/mp.2016.140. PubMed PMID: 27528461; PubMed Central PMCID: PMC5030463