WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510334
Description: CM-352 is a potent MMP inhibitor, which inhibited fibrinolysis in human whole blood functional assays and was more effective than the current standard of care, tranexamic acid, in the tail-bleeding model using a 30,000 times lower dose. Moreover, CM-352 reduced blood loss during liver hepatectomy. CM352 displayed optimal pharmacokinetic and safety profiles with no evidence of thrombosis or coagulation impairment. This novel mechanism of action, targeting MMP, defines a new class of antihemorrhagic agents without interfering with normal hemostatic function. Furthermore, CM-352 represents a pre-clinical candidate for the acute treatment of bleeding.
MedKoo Cat#: 510334
Chemical Formula: C24H29N3O6S
Exact Mass: 487.17771
Molecular Weight: 487.57
Elemental Analysis: C, 59.12; H, 6.00; N, 8.62; O, 19.69; S, 6.58
Synonym: CM352; CM 352; CM-352.
IUPAC/Chemical Name: (R)-N-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide
InChi Key: ZUZGJCNWNOCKEB-XMMPIXPASA-N
InChi Code: InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m1/s1
SMILES Code: O=C(NC)C1=CC=C(OC2=CC=C(S(=O)([C@]3(C(NO)=O)CCC4(CCNCC4)C3)=O)C=C2)C=C1.
1: Orbe J, Rodriguez JA, Sanchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Paramo JA. Discovery and safety profiling of a potent pre-clinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methyl-benzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem. 2015 Feb 16. [Epub ahead of print] PubMed PMID: 25686022.