Bedaquiline
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MedKoo CAT#: 314214

CAS#: 843663-66-1 (free base)

Description: Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. When it was approved by the FDA on the 28th December 2012, it was the first new medicine to fight TB in more than forty years, and is specifically approved to treat multi-drug-resistant tuberculosis.


Price and Availability

Size
Price

50mg
USD 150
500mg
USD 850
5g
USD 2650
50g
USD 12650
Size
Price

100mg
USD 250
1g
USD 1450
10g
USD 4650
Size
Price

200mg
USD 450
2g
USD 1950
20g
USD 5950

Bedaquiline, purity > 98%, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 314214
Name: Bedaquiline
CAS#: 843663-66-1 (free base)
Chemical Formula: C32H31BrN2O2
Exact Mass: 554.15689
Molecular Weight: 555.5
Elemental Analysis: C, 69.19; H, 5.62; Br, 14.38; N, 5.04; O, 5.76


Synonym: TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910; Bedaquiline; Bedaquiline fumarate; trade name Sirturo,

IUPAC/Chemical Name: (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol

InChi Key: QUIJNHUBAXPXFS-XLJNKUFUSA-N

InChi Code: InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

SMILES Code: O[C@](CCN(C)C)(C1=C2C=CC=CC2=CC=C1)[C@@H](C3=CC4=CC(Br)=CC=C4N=C3OC)C5=CC=CC=C5


Technical Data

Appearance:
solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO.

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
843663-66-1 (Bedaquiline); 845533-86-0 (Bedaquiline fumarate).


References

1: van Heeswijk RP, Dannemann B, Hoetelmans RM. Bedaquiline: a review of human pharmacokinetics and drug-drug interactions. J Antimicrob Chemother. 2014 May 23. pii: dku171. [Epub ahead of print] Review. PubMed PMID: 24860154.

2: Kakkar AK, Dahiya N. Bedaquiline for the treatment of resistant tuberculosis: Promises and pitfalls. Tuberculosis (Edinb). 2014 Apr 18. pii: S1472-9792(14)20416-1. doi: 10.1016/j.tube.2014.04.001. [Epub ahead of print] Review. PubMed PMID: 24841672.

3: Lakshmanan M, Xavier AS. Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis. J Young Pharm. 2013 Dec;5(4):112-115. Epub 2013 Dec 30. Review. PubMed PMID: 24563587; PubMed Central PMCID: PMC3930122.

4: Palomino JC, Martin A. TMC207 becomes bedaquiline, a new anti-TB drug. Future Microbiol. 2013 Sep;8(9):1071-80. doi: 10.2217/fmb.13.85. Review. PubMed PMID: 24020736.

5: Gras J. Bedaquiline for the treatment of pulmonary, multidrug-resistant tuberculosis in adults. Drugs Today (Barc). 2013 Jun;49(6):353-61. doi: 10.1358/dot.2013.49.6.1970865. Review. PubMed PMID: 23807939.