YL-109
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MedKoo CAT#: 406591

CAS#: 36341-25-0

Description: YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures. YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein (CHIP), which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway. YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor (AhR) to upstream of CHIP gene in MDA-MB-231 cells. Consistently, the antitumor effects of YL-109 were depressed by CHIP or AhR knockdown in MDA-MB-231 cells. YL-109 inhibits cell growth and metastatic potential by inducing CHIP expression through AhR signaling and reduces cancer stem cell properties in MDA-MB-231 cells.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 350
1g
USD 1450
Size
Price

25mg
USD 150
200mg
USD 550
2g
USD 2250
Size
Price

50mg
USD 250
500mg
USD 850
5g
Ask price

YL-109, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406591
Name: YL-109
CAS#: 36341-25-0
Chemical Formula: C14H11NO2S
Exact Mass: 257.05105
Molecular Weight: 257.31
Elemental Analysis: C, 65.35; H, 4.31; N, 5.44; O, 12.44; S, 12.46


Synonym: YL109; YP-109; YP 109.

IUPAC/Chemical Name: 4-(benzo[d]thiazol-2-yl)-2-methoxyphenol

SMILES Code: COC1=CC(C2=NC3=CC=CC=C3S2)=CC=C1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

 1: Hiyoshi H, Goto N, Tsuchiya M, Iida K, Nakajima Y, Hirata N, Kanda Y, Nagasawa K, Yanagisawa J. 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP. Sci Rep. 2014 Nov 18;4:7095. doi: 10.1038/srep07095. PubMed PMID: 25403352; PubMed Central PMCID: PMC4235287.