XR3054

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406467

CAS#: 247090-97-7

Description: XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.2, 21.4 and 8.8 microM, respectively) but was relatively inactive when tested against a panel of breast carcinoma cell lines. The activity did not relate to the presence of mutant or wild-type ras in the cell lines tested. In conclusion XR3054 inhibits ras farnesylation, MAP kinase activation and anchorage-independent growth in NIH 3T3 transformed with v12 H-ras. Since the antiproliferative effect of the compound is not related to the ras phenotype, XR3054 may also have effects on other cell signaling mechanisms.


Price and Availability

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Price

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XR3054 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406467
Name: XR3054
CAS#: 247090-97-7
Chemical Formula: C13H22O2
Exact Mass: 210.16198
Molecular Weight: 210.31258
Elemental Analysis: C, 74.24; H, 10.54; O, 15.21


Synonym: XR3054; XR-3054; XR 3054.

IUPAC/Chemical Name: (5s,8s)-2,2-dimethyl-8-(prop-1-en-2-yl)-1,3-dioxaspiro[4.5]decane

InChi Key: PUEZSVQWMHEGRF-BJHJDKERSA-N

InChi Code: InChI=1S/C13H22O2/c1-10(2)11-5-7-13(8-6-11)9-14-12(3,4)15-13/h11H,1,5-9H2,2-4H3/t11-,13+

SMILES Code: C=C([C@@H](CC1)CC[C@]21COC(C)(C)O2)C


Technical Data

Appearance:
White solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Donaldson MJ, Skoumas V, Watson M, Ashworth PA, Ryder H, Moore M, Coombes RC. XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. Eur J Cancer. 1999 Jun;35(6):1014-9. PubMed PMID: 10533487.