XAV-939
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406134

CAS#: 284028-89-3

Description: XAV-939 is a Tankyrase (TNKS) inhibitor with potential anticancer activity. XAV-939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV-939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 1950
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 2950
Size
Price

50mg
USD 250
500mg
USD 1250
5g
Ask price

XAV-939, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406134
Name: XAV-939
CAS#: 284028-89-3
Chemical Formula: C14H11F3N2OS
Exact Mass: 312.05442
Molecular Weight: 312.31
Elemental Analysis: C, 53.84; H, 3.55; F, 18.25; N, 8.97; O, 5.12; S, 10.27


Synonym: XAV939; XAV 939; XAV-939.

IUPAC/Chemical Name: 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one

InChi Key: KLGQSVMIPOVQAX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)

SMILES Code: O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1


Technical Data

Appearance:
White Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A, Distler O, Schett G, Distler JH. Inactivation of tankyrases reduces  experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2012 Nov 12. [Epub ahead of print] PubMed PMID: 23148305.