WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406353
Description: WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.
MedKoo Cat#: 406353
Chemical Formula: C16H14FN3O
Exact Mass: 283.11209
Molecular Weight: 283.3
Elemental Analysis: C, 67.83; H, 4.98; F, 6.71; N, 14.83; O, 5.65
Synonym: WAY255348; WAY-255348; WAY 255348.
IUPAC/Chemical Name: 5-(7-fluoro-3,3-dimethyl-2-oxoindolin-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile
InChi Key: KIOOLNRTWPFVHX-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
SMILES Code: N#CC1=CC=C(C2=CC3=C(NC(C3(C)C)=O)C(F)=C2)N1C
1: Yudt MR, Russo LA, Berrodin TJ, Jelinsky SA, Ellis D, Cohen JC, Cooch N, Haglund E, Unwalla RJ, Fensome A, Wrobel J, Zhang Z, Nagpal S, Winneker RC. Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions. Biochem Pharmacol. 2011 Dec 1;82(11):1709-19. doi: 10.1016/j.bcp.2011.08.006. Epub 2011 Aug 11. PubMed PMID: 21854761.