WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406242
Description: Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.
MedKoo Cat#: 406242
Chemical Formula: C21H20N6O2S3
Exact Mass: 484.08099
Molecular Weight: 484.62
Elemental Analysis: C, 52.05; H, 4.16; N, 17.34; O, 6.60; S, 19.85
IUPAC/Chemical Name: 2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid
SMILES Code: O=C(O)CSC1=NN=C(CSC2=NC(N)=C(C3=C(CCCC3)S4)C4=N2)N1C5=CC=CC=C5
1: Ding X, Yan F, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, Yao X. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 2010 Dec;20(12):1386-9. doi: 10.1038/cr.2010.167. Epub 2010 Nov 30. PubMed PMID: 21119683; PubMed Central PMCID: PMC3107503.