PF-376304

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406321

CAS#: 851757-93-2

Description: PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.


Price and Availability

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Price

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PF376304 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406321
Name: PF-376304
CAS#: 851757-93-2
Chemical Formula: C17H24N8O3
Exact Mass: 388.19714
Molecular Weight: 388.42426
Elemental Analysis: C, 52.57; H, 6.23; N, 28.85; O, 12.36


Synonym: PF376304; PF 376304; PF-376304.

IUPAC/Chemical Name: 4-(cycloheptyloxy)-2-morpholino-N-(2H-tetrazol-5-yl)pyrimidine-5-carboxamide

SMILES Code: O=C(C1=CN=C(N2CCOCC2)N=C1OC3CCCCCC3)NC4=NNN=N4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition:
0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly.

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Robertson DG, Datta K, Wells D, Egnash L, Robosky L, Manning M, Rohde C, Reily MD. Metabonomic evaluation of metabolic dysregulation in rats induced by PF376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol. 2007 Dec;20(12):1871-7. Epub 2007 Nov 15. PubMed PMID: 18001061.