PD318088

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406195

CAS#: 391210-00-7

Description: PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.


Price and Availability

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10mg
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100mg
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1g
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10g
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25mg
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200mg
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2g
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20g
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50mg
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500mg
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5g
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PD318088 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406195
Name: PD318088
CAS#: 391210-00-7
Chemical Formula: C16H13BrF3IN2O4
Exact Mass: 559.90555
Molecular Weight: 561.09
Elemental Analysis: C, 34.25; H, 2.34; Br, 14.24; F, 10.16; I, 22.62; N, 4.99; O, 11.41


Synonym: PD318088; PD 318088; PD318088.

IUPAC/Chemical Name: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

InChi Key: XXSSGBYXSKOLAM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H13BrF3IN2O4/c17-10-4-9(16(26)23-27-6-8(25)5-24)15(14(20)13(10)19)22-12-2-1-7(21)3-11(12)18/h1-4,8,22,24-25H,5-6H2,(H,23,26)

SMILES Code: O=C(NOCC(O)CO)C1=CC(Br)=C(F)C(F)=C1NC2=CC=C(I)C=C2F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Han S, Zhou V, Pan S, Liu Y, Hornsby M, McMullan D, Klock HE, Haugen J, Lesley SA, Gray N, Caldwell J, Gu XJ. Identification of coumarin derivatives as a novel  class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73. Epub 2005 Sep 30. PubMed PMID: 16199156.