PD-168393
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406105

CAS#: 194423-15-9

Description: PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).


Price and Availability

Size
Price

100mg
USD 350
1g
USD 1850
Size
Price

200mg
USD 650
2g
USD 3250
Size
Price

500mg
USD 1250
5g
Ask price

PD-168393, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406105
Name: PD-168393
CAS#: 194423-15-9
Chemical Formula: C17H13BrN4O
Exact Mass: 368.02727
Molecular Weight: 369.21
Elemental Analysis: C, 55.30; H, 3.55; Br, 21.64; N, 15.17; O, 4.33


Synonym: PD168393; PD 168393; PD-168393.

IUPAC/Chemical Name: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

InChi Key: HTUBKQUPEREOGA-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)

SMILES Code: C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not soluble in water.

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Skelton LA, Boron WF. Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1747-64. doi: 10.1152/ajprenal.00307.2013. Epub 2013 Oct 16. PubMed PMID: 24133121; PubMed Central PMCID: PMC3882443.

2: Poole NM, Nyindodo-Ogari L, Kramer C, Coons LB, Cole JA. Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. Ticks Tick Borne Dis. 2013 Feb;4(1-2):120-7. doi: 10.1016/j.ttbdis.2012.09.003. Epub 2012 Nov 16. PubMed PMID: 23168047.

3: Turpaev K, Drapier JC. Stimulatory effect of benzylidenemalononitrile tyrphostins on expression of NO-dependent genes in U-937 monocytic cells. Eur J Pharmacol. 2009 Mar 15;606(1-3):1-8. doi: 10.1016/j.ejphar.2009.01.015. Epub 2009 Jan 21. PubMed PMID: 19374863.

4: Hammoud L, Burger DE, Lu X, Feng Q. Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. Am J Physiol Cell Physiol. 2009 Apr;296(4):C735-45. doi: 10.1152/ajpcell.00246.2008. Epub 2009 Feb 11. PubMed PMID: 19211917.

5: Khalil MY, Grandis JR, Shin DM. Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer. Expert Rev Anticancer Ther. 2003 Jun;3(3):367-80. Review. PubMed PMID: 12820779.

6: Sun Y, Fry DW, Vincent P, Nelson JM, Elliott W, Leopold WR. Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine kinase inhibitors. Anticancer Res. 1999 Mar-Apr;19(2A):919-24. PubMed PMID: 10368634.