WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406314
Description: OXi8007 is a vascular disrupting agent with potential anticancer activity. OXi8007 was found to be strongly cytotoxic against selected human cancer cell lines (GI50 = 36 nM against DU-145 cells, for example). OXi8007 also demonstrated pronounced interference with tumor vasculature in a preliminary in vivo study utilizing a SCID mouse model bearing an orthotopic PC-3 (prostate) tumor as imaged by color Doppler ultrasound. OXi8007 may be useful for the treatment of cancer.
MedKoo Cat#: 406314
Chemical Formula: C26H26NO10P
Exact Mass: 543.12943
Molecular Weight: 543.46
Elemental Analysis: C, 57.46; H, 4.82; N, 2.58; O, 29.44; P, 5.70
Synonym: OXi8007; OXi-8007; OXi 8007.
IUPAC/Chemical Name: sodium 2-methoxy-5-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-2-yl)phenyl phosphate
SMILES Code: O=P([O-])([O-])OC1=CC(C(N2)=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C4=C2C=C(OC)C=C4)=CC=C1OC.[Na+].[Na+]
1: Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9. PubMed PMID: 24016002.