WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406513
Description: MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of the mitotic marker MPM-2. Furthermore, the compound induced apoptotic cell death through mitochondria/caspase 9-dependent pathway. Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. ( PLoS One. 2013;8(3):e58953).
MedKoo Cat#: 406513
Chemical Formula: C20H20N2O5
Exact Mass: 368.13722
Molecular Weight: 368.38
Elemental Analysis: C, 65.21; H, 5.47; N, 7.60; O, 21.72
Synonym: MPT0B214; MPT 0B214; MPT-0B214
IUPAC/Chemical Name: (5-amino-6-methoxyquinolin-2-yl)(3,4,5-trimethoxyphenyl)methanone
InChi Key: HBQYPNDXFXSVNP-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N2O5/c1-24-15-8-7-13-12(18(15)21)5-6-14(22-13)19(23)11-9-16(25-2)20(27-4)17(10-11)26-3/h5-10H,21H2,1-4H3
SMILES Code: O=C(C1=NC2=CC=C(OC)C(N)=C2C=C1)C3=CC(OC)=C(OC)C(OC)=C3
1: Chiang NJ, Lin CI, Liou JP, Kuo CC, Chang CY, Chen LT, Chang JY. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway. PLoS One. 2013;8(3):e58953. doi: 10.1371/journal.pone.0058953. Epub 2013 Mar 12. PubMed PMID: 23554962; PubMed Central PMCID: PMC3595215.