WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406283
Description: META060 is multikinase inhibitor, which inhibits the activity of kinases (spleen tyrosine kinase, Bruton's tyrosine kinase, phosphatidylinositol 3-kinase, and GSK3) associated with RA and inhibits beta-catenin phosphorylation. META060 also inhibits osteoclastogenesis as wells as inhibits IL-1beta-activated prostaglandin E(2), matrix metalloproteinase 3, IL-6, IL-8, and monocyte chemotactic protein 1 in RASFs. In mice with acute inflammation, oral administration of META060 reduced paw swelling similar to the effect of aspirin. In mice with CIA, META060 significantly reduced the arthritis index and decreased bone, joint, and cartilage degradation. Serum IL-6 concentrations in these mice were inhibited in a dose-dependent manner. META060 may have therapeutic potential in the treatment of inflammatory diseases. (Arthritis Rheum. 2010 Jun;62(6):1683-92 )
MedKoo Cat#: 406283
Synonym: META-060; META060; META 060
IUPAC/Chemical Name: Unknown
1: Vroegrijk IO, van Diepen JA, van den Berg SA, Romijn JA, Havekes LM, van Dijk KW, Darland G, Konda V, Tripp ML, Bland JS, Voshol PJ. META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse. Nutrition. 2013 Jan;29(1):276-83. doi: 10.1016/j.nut.2012.05.004. Epub 2012 Sep 15. PubMed PMID: 22985971.
2: Desai A, Darland G, Bland JS, Tripp ML, Konda VR. META060 attenuates TNF-α-activated inflammation, endothelial-monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes. Atherosclerosis. 2012 Jul;223(1):130-6. doi: 10.1016/j.atherosclerosis.2012.05.004. Epub 2012 May 15. PubMed PMID: 22658256.
3: Everard A, Geurts L, Van Roye M, Delzenne NM, Cani PD. Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice. PLoS One. 2012;7(3):e33858. doi: 10.1371/journal.pone.0033858. Epub 2012 Mar 28. PubMed PMID: 22470484; PubMed Central PMCID: PMC3314685.
4: Konda VR, Desai A, Darland G, Bland JS, Tripp ML. META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis. Arthritis Rheum. 2010 Jun;62(6):1683-92. doi: 10.1002/art.27441. PubMed PMID: 20201075.
5: Desai A, Konda VR, Darland G, Austin M, Prabhu KS, Bland JS, Carroll BJ, Tripp ML. META060 inhibits multiple kinases in the NF-kappaB pathway and suppresses LPS--mediated inflammation in vitro and ex vivo. Inflamm Res. 2009 May;58(5):229-34. doi: 10.1007/s00011-008-8162-y. PubMed PMID: 19169645.