META060

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406283

CAS#: unknown

Description: META060 is multikinase inhibitor, which inhibits the activity of kinases (spleen tyrosine kinase, Bruton's tyrosine kinase, phosphatidylinositol 3-kinase, and GSK3) associated with RA and inhibits beta-catenin phosphorylation. META060 also inhibits osteoclastogenesis as wells as inhibits IL-1beta-activated prostaglandin E(2), matrix metalloproteinase 3, IL-6, IL-8, and monocyte chemotactic protein 1 in RASFs. In mice with acute inflammation, oral administration of META060 reduced paw swelling similar to the effect of aspirin. In mice with CIA, META060 significantly reduced the arthritis index and decreased bone, joint, and cartilage degradation. Serum IL-6 concentrations in these mice were inhibited in a dose-dependent manner. META060 may have therapeutic potential in the treatment of inflammatory diseases. (Arthritis Rheum. 2010 Jun;62(6):1683-92 )


Price and Availability

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Price

Size
Price

Size
Price

META060 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

No image available

Theoretical Analysis

MedKoo Cat#: 406283
Name: META060
CAS#: unknown
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:


Synonym: META-060; META060; META 060

IUPAC/Chemical Name: Unknown


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Vroegrijk IO, van Diepen JA, van den Berg SA, Romijn JA, Havekes LM, van Dijk KW, Darland G, Konda V, Tripp ML, Bland JS, Voshol PJ. META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse. Nutrition. 2013 Jan;29(1):276-83. doi: 10.1016/j.nut.2012.05.004. Epub 2012 Sep 15. PubMed PMID: 22985971.

2: Desai A, Darland G, Bland JS, Tripp ML, Konda VR. META060 attenuates TNF-α-activated inflammation, endothelial-monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes. Atherosclerosis. 2012 Jul;223(1):130-6. doi: 10.1016/j.atherosclerosis.2012.05.004. Epub 2012 May 15. PubMed PMID: 22658256.

3: Everard A, Geurts L, Van Roye M, Delzenne NM, Cani PD. Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice. PLoS One. 2012;7(3):e33858. doi: 10.1371/journal.pone.0033858. Epub 2012 Mar 28. PubMed PMID: 22470484; PubMed Central PMCID: PMC3314685.

4: Konda VR, Desai A, Darland G, Bland JS, Tripp ML. META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis. Arthritis Rheum. 2010 Jun;62(6):1683-92. doi: 10.1002/art.27441. PubMed PMID: 20201075.

5: Desai A, Konda VR, Darland G, Austin M, Prabhu KS, Bland JS, Carroll BJ, Tripp ML. META060 inhibits multiple kinases in the NF-kappaB pathway and suppresses LPS--mediated inflammation in vitro and ex vivo. Inflamm Res. 2009 May;58(5):229-34. doi: 10.1007/s00011-008-8162-y. PubMed PMID: 19169645.