KU-0058684

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406358

CAS#: 623578-11-0

Description: KU-0058684 is a potent PARP and DNA-PK inhibitors.


Price and Availability

Size
Price

10mg
Not available
100mg
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1g
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Size
Price

25mg
Not available
200mg
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2g
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Size
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50mg
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500mg
Not available
5g
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KU-0058684 is not in stock, but is available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406358
Name: KU-0058684
CAS#: 623578-11-0
Chemical Formula: C19H14FN3O3
Exact Mass: 351.10192
Molecular Weight: 351.33
Elemental Analysis: C, 64.95; H, 4.02; F, 5.41; N, 11.96; O, 13.66


Synonym: KU0058684; KU-0058684; KU 0058684; KU58684; KU 58684; KU-58684

IUPAC/Chemical Name: 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione

InChi Key: YQSZNYLPVBOGPO-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14FN3O3/c20-14-6-5-11(10-16(14)23-17(24)7-8-18(23)25)9-15-12-3-1-2-4-13(12)19(26)22-21-15/h1-6,10H,7-9H2,(H,22,26)

SMILES Code: O=C(CC1)N(C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Sousa MM, Zub KA, Aas PA, Hanssen-Bauer A, Demirovic A, Sarno A, Tian E, Liabakk NB, Slupphaug G. An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLoS One. 2013;8(2):e55493. doi: 10.1371/journal.pone.0055493. Epub 2013 Feb 6. PubMed PMID: 23405159; PubMed Central PMCID: PMC3566207.

2: Urbin SS, Elvers I, Hinz JM, Helleday T, Thompson LH. Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells. Environ Mol Mutagen. 2012 Mar;53(2):114-24. doi: 10.1002/em.21672. Epub 2012 Jan 4. PubMed PMID: 22302683.