GTP-14564
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406205

CAS#: 34823-86-4

Description: GTP-14564 is a specific kinase inhibitor for ITD-FLT3. GTP-14564 inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3 at 1 microM, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).


Price and Availability

Size
Price

5mg
USD 270
Size
Price

Size
Price

GTP-14564, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406205
Name: GTP-14564
CAS#: 34823-86-4
Chemical Formula: C15H10N2O
Exact Mass: 234.07931
Molecular Weight: 234.25
Elemental Analysis: C, 76.91; H, 4.30; N, 11.96; O, 6.83


Synonym: GTP14564; GTP 14564; GTP-14564

IUPAC/Chemical Name: 3-phenyl-1H-benzofuro[3,2-c]pyrazole

InChi Key: DZQLVVLATXPWBK-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)

SMILES Code: C12=C(OC3=CC=CC=C32)C(C4=CC=CC=C4)=NN1


Technical Data

Appearance:
Solid powder

Purity:
>98%

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Yao Q, Nishiuchi R, Kitamura T, Kersey JH. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia. 2005 Sep;19(9):1605-12. PubMed PMID: 16034464.

2: Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18. PubMed PMID: 12815052.