CX-6258
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406247

CAS#: 1202916-90-2 (free base)

Description: CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2850
Size
Price

25mg
USD 250
200mg
USD 1250
2g
Ask price
Size
Price

50mg
USD 450
500mg
USD 1850
5g
Ask price

CX-6258, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 1g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406247
Name: CX-6258
CAS#: 1202916-90-2 (free base)
Chemical Formula: C26H24ClN3O3
Exact Mass: 461.15062
Molecular Weight: 461.94
Elemental Analysis: C, 67.60; H, 5.24; Cl, 7.67; N, 9.10; O, 10.39


Synonym: CX6258; CX-6258; CX 6258.

IUPAC/Chemical Name: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one

InChi Key: KGBPLKOPSFDBOX-CJLVFECKSA-N

InChi Code: InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+

SMILES Code: O=C1NC2=C(C=C(Cl)C=C2)/C1=C\C3=CC=C(C4=CC=CC(C(N5CCN(C)CCC5)=O)=C4)O3


Technical Data

Appearance:
orange solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
1202916-90-2 (CX-6258 free base);
1353858-99-7 (CX-6258 HCl salt, hydrate).
 


References

1. Mustapha Haddach *, Jerome Michaux , Michael K. Schwaebe , Fabrice Pierre , Sean E. O’Brien , Cosmin Borsan , Joe Tran , Nicholas Raffaele , Suchitra Ravula , Denis Drygin , Adam Siddiqui-Jain , Levan Darjania , Ryan Stansfield , Chris Proffitt , Diwata Macalino , Nicole Streiner , Joshua Bliesath , May Omori , Jeffrey P. Whitten , Kenna Anderes , William G. Rice , and David M. Ryckman. ACS Med. Chem. Lett., 2012, 3 (2), pp 135–139.