CNX-2006

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406482

CAS#: 1375465-09-0

Description: CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.


Price and Availability

Size
Price

10mg
Not available
100mg
Not available
1g
USD 3450
10g
Ask price
Size
Price

25mg
Not available
200mg
Not available
2g
USD 4950
20g
Ask price
Size
Price

50mg
Not available
500mg
Not available
5g
USD 7950

CNX-2006, purity > 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406482
Name: CNX-2006
CAS#: 1375465-09-0
Chemical Formula: C26H27F4N7O2
Exact Mass: 545.21624
Molecular Weight: 545.53189
Elemental Analysis: C, 57.24; H, 4.99; F, 13.93; N, 17.97; O, 5.87


Synonym: CNX2006; CNX 2006; CNX-2006.

IUPAC/Chemical Name: N-(3-((2-((4-((1-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

InChi Key: BFSRTTWIPACGMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27F4N7O2/c1-3-23(38)33-16-5-4-6-17(11-16)34-24-20(26(28,29)30)13-31-25(36-24)35-21-8-7-18(12-22(21)39-2)32-19-14-37(15-19)10-9-27/h3-8,11-13,19,32H,1,9-10,14-15H2,2H3,(H,33,38)(H2,31,34,35,36)

SMILES Code: C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(NC4CN(CCF)C4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

CNX-2006 is a Me-Too version of CO-1686, which structures are compared as below:   
 
 
 


References