BRN-103

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401156

CAS#: 1346265-80-2

Description: BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.

Chemical Structure

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BRN-103
CAS# 1346265-80-2
Instruction

Theoretical Analysis

MedKoo Cat#: 401156
Name: BRN-103
CAS#: 1346265-80-2
Chemical Formula: C24H25ClN4O
Exact Mass: 420.17
Molecular Weight: 420.935
Elemental Analysis: C, 68.48; H, 5.99; Cl, 8.42; N, 13.31; O, 3.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BRN103; BRN103; BRN 103

IUPAC/Chemical Name: 2-((1-benzylpiperidin-4-yl)amino)-N-(3-chlorophenyl)nicotinamide

InChi Key: FJLKVQYKXSXIPA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H25ClN4O/c25-19-8-4-9-21(16-19)28-24(30)22-10-5-13-26-23(22)27-20-11-14-29(15-12-20)17-18-6-2-1-3-7-18/h1-10,13,16,20H,11-12,14-15,17H2,(H,26,27)(H,28,30)

SMILES Code: O=C(NC1=CC=CC(Cl)=C1)C2=C(NC3CCN(CC4=CC=CC=C4)CC3)N=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Choi HE, Yoo MS, Choi JH, Lee JY, Kim JH, Kim JH, Lee JK, Kim GI, Park Y, Chi YH, Paik SH, Lee JH, Lee KT. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6236-41. doi: 10.1016/j.bmcl.2011.09.022. Epub 2011 Sep 13. PubMed PMID: 21963305.