BRN-103

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401156

CAS#: 1346265-80-2

Description: BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.


Price and Availability

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BRN-103, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 401156
Name: BRN-103
CAS#: 1346265-80-2
Chemical Formula: C24H25ClN4O
Exact Mass: 420.17169
Molecular Weight: 420.9345
Elemental Analysis: C, 68.48; H, 5.99; Cl, 8.42; N, 13.31; O, 3.80


Synonym: BRN103; BRN103; BRN 103

IUPAC/Chemical Name: 2-((1-benzylpiperidin-4-yl)amino)-N-(3-chlorophenyl)nicotinamide

InChi Key: FJLKVQYKXSXIPA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H25ClN4O/c25-19-8-4-9-21(16-19)28-24(30)22-10-5-13-26-23(22)27-20-11-14-29(15-12-20)17-18-6-2-1-3-7-18/h1-10,13,16,20H,11-12,14-15,17H2,(H,26,27)(H,28,30)

SMILES Code: O=C(NC1=CC=CC(Cl)=C1)C2=C(NC3CCN(CC4=CC=CC=C4)CC3)N=CC=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Choi HE, Yoo MS, Choi JH, Lee JY, Kim JH, Kim JH, Lee JK, Kim GI, Park Y, Chi YH, Paik SH, Lee JH, Lee KT. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6236-41. doi: 10.1016/j.bmcl.2011.09.022. Epub 2011 Sep 13. PubMed PMID: 21963305.