AG-1024

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406233

CAS#: 65678-07-1

Description: AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.


Price and Availability

Size
Price

1g
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Size
Price

2g
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Size
Price

5g
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AG-1024, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406233
Name: AG-1024
CAS#: 65678-07-1
Chemical Formula: C14H13BrN2O
Exact Mass: 304.02113
Molecular Weight: 305.16982
Elemental Analysis: C, 55.10; H, 4.29; Br, 26.18; N, 9.18; O, 5.24


Synonym: AG1024; AG-1024; AG 1024. Tyrphostin.

IUPAC/Chemical Name: 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile

InChi Key: ABBADGFSRBWENF-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3

SMILES Code: N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(Br)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Wen B, Deutsch E, Marangoni E, Frascona V, Maggiorella L, Abdulkarim B, Chavaudra N, Bourhis J. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21. PubMed PMID: 11747348; PubMed Central PMCID: PMC2364012.