ABC294735

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406470

CAS#: 917236-13-6

Description: ABC294735 is a dual SK1/SK2 inhibitor with potential anticancer activity.


Price and Availability

Size
Price

10mg
Not available
100mg
Not available
1g
Ask price
Size
Price

25mg
Not available
200mg
Not available
2g
Ask price
Size
Price

50mg
Not available
500mg
Not available
5g
Ask price

ABC294735, purity > 98%, may be available through custom synthesis . Minimum 1 gram order is requested. Lead time is usually 2-3 months. Please email us to ask quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 406470
Name: ABC294735
CAS#: 917236-13-6
Chemical Formula: C24H26ClNO3
Exact Mass: 411.16012
Molecular Weight: 411.92114
Elemental Analysis: C, 69.98; H, 6.36; Cl, 8.61; N, 3.40; O, 11.65


Synonym: ABC294735; ABC-294735; ABC 294735.

IUPAC/Chemical Name: (1s,3r,5R,7S)-3-(4-chlorophenyl)-N-(3,4-dihydroxybenzyl)adamantane-1-carboxamide

InChi Key: KNZHUAFGWMRPPB-NBKKPGCJSA-N

InChi Code: InChI=1S/C24H26ClNO3/c25-19-4-2-18(3-5-19)23-9-16-7-17(10-23)12-24(11-16,14-23)22(29)26-13-15-1-6-20(27)21(28)8-15/h1-6,8,16-17,27-28H,7,9-14H2,(H,26,29)/t16-,17+,23+,24-

SMILES Code: O=C([C@@]12C[C@]3(C4=CC=C(Cl)C=C4)C[C@@](C2)([H])C[C@](C3)([H])C1)NCC5=CC=C(O)C(O)=C5


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Gao P, Peterson YK, Smith RA, Smith CD. Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One. 2012;7(9):e44543. doi: 10.1371/journal.pone.0044543. Epub 2012 Sep 10. PubMed PMID: 22970244; PubMed Central PMCID: PMC3438171.

2: Beljanski V, Knaak C, Zhuang Y, Smith CD. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011 Dec;29(6):1132-42. doi: 10.1007/s10637-010-9452-0. Epub 2010 May 18. PubMed PMID: 20473784; PubMed Central PMCID: PMC3089696.