A-674563
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401012

CAS#: 552325-73-2

Description: A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.


Price and Availability

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Price

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A-674563, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 401012
Name: A-674563
CAS#: 552325-73-2
Chemical Formula: C22H22N4O
Exact Mass: 358.17936
Molecular Weight: 358.43628
Elemental Analysis: C, 73.72; H, 6.19; N, 15.63; O, 4.46


Synonym: A674563; A 674563; A-674563

IUPAC/Chemical Name: (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine

InChi Key: BPNUQXPIQBZCMR-IBGZPJMESA-N

InChi Code: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1

SMILES Code: N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

 1: Tei H, Miyake H, Fujisawa M. Enhanced sensitivity to sorafenib by inhibition
of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in
vivo. Hum Cell. 2015 Apr 11. [Epub ahead of print] PubMed PMID: 25862630.