TXA127

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205655

CAS#: 51833-78-4

Description: TXA127, also known as Angiotensin i (1-7), is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway.


Price and Availability

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TXA127 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205655
Name: TXA127
CAS#: 51833-78-4
Chemical Formula: C41H62N12O11
Exact Mass: 898.4661
Molecular Weight: 899.02
Elemental Analysis: C, 54.78; H, 6.95; N, 18.70; O, 19.58


Synonym: TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)

IUPAC/Chemical Name: L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

InChi Key: PVHLMTREZMEJCG-GDTLVBQBSA-N

InChi Code: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)CCC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

In 2010, TXA127 was granted Orphan Drug designation as a treatment to enhance engraftment in patients receiving a stem cell transplant. TXA127 has also received Orphan Drug designation for the treatment of Myelodysplastic Syndrome (MDS).
  
 
 


References

 1: Ábrigo J, Simon F, Cabrera D, Cabello-Verrugio C. Angiotensin-(1-7) Prevents
Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β)
via Mas Receptor Activation. Cell Physiol Biochem. 2016 Nov 14;40(1-2):27-38.
[Epub ahead of print] PubMed PMID: 27842312.

2: Magalhães GS, Rodrigues-Machado MD, Motta-Santos D, Alenina N, Bader M, Santos
RA, Barcelos LS, Campagnole-Santos MJ. CHRONIC ALLERGIC PULMONARY INFLAMMATION IS
AGGRAVATED IN ANGIOTENSIN-(1-7) MAS RECEPTOR KNOCKOUT MICE. Am J Physiol Lung
Cell Mol Physiol. 2016 Nov 4:ajplung.00029.2016. doi: 10.1152/ajplung.00029.2016.
[Epub ahead of print] PubMed PMID: 27815255.

3: Yu L, Yuan K, Phuong HT, Park BM, Kim SH. Angiotensin-(1-5), an active
mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor.
Peptides. 2016 Sep 20;86:33-41. doi: 10.1016/j.peptides.2016.09.009. [Epub ahead
of print] PubMed PMID: 27660028.

4: Brosnihan KB, M Pulgar V, Bharadwaj MS, Neves LA, Yamaleyeva LM. Local
intra-uterine Ang-(1-7) infusion attenuates PGE(2) and 6-keto PGF(1α) in
decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2016 Oct
18;14(1):68. PubMed PMID: 27756404; PubMed Central PMCID: PMC5070151.