AZD-0780
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556369

CAS#: 2455427-91-3

Description: AZD0780, also known as EX-A6975, is a PCSK9 Inhibitor. AZD-0780 exhibits bind affinity for PCSK9 ( Kd <200 nM). AZD0780 has research value in cholesterol metabolism.

Chemical Structure

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AZD-0780
CAS# 2455427-91-3
Instruction

Theoretical Analysis

MedKoo Cat#: 556369
Name: AZD-0780
CAS#: 2455427-91-3
Chemical Formula: C20H20F2N6O2
Exact Mass: 414.16
Molecular Weight: 414.417
Elemental Analysis: C, 57.97; H, 4.86; F, 9.17; N, 20.28; O, 7.72

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
10mg USD 950 2 Weeks
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Synonym: AZD0780; AZD0780; AZD0780; EX-A6975; EX-A 6975; EXA6975;

IUPAC/Chemical Name: 6'-(((1S,3S)-3-((5-(difluoromethoxy)pyrimidin-2-yl)amino)cyclopentyl)amino)-2H-[1,3'-bipyridin]-2-one

InChi Key: NCHUWRLOTSAFFN-KBPBESRZSA-N

InChi Code: InChI=1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6-15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26)(H,24,25,27)/t13-,14-/m0/s1

SMILES Code: O=C1N(C=CC=C1)C2=CN=C(N[C@@H]3C[C@H](CC3)NC4=NC=C(OC(F)F)C=N4)C=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 414.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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