Bimiralisib free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206146

CAS#: 1225037-39-7 (free base)

Description: Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PQR309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2850
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 4250
Size
Price

50mg
USD 450
500mg
USD 2150
5g
USD 6750

Bimiralisib free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206146
Name: Bimiralisib free base
CAS#: 1225037-39-7 (free base)
Chemical Formula: C17H20F3N7O2
Exact Mass: 411.1631
Molecular Weight: 411.3892
Elemental Analysis: C, 49.63; H, 4.90; F, 13.85; N, 23.83; O, 7.78


Related CAS #: 1820902-72-4 (HCl salt)   1225037-39-7 (free base)    

Synonym: PQR309; PQR-309; PQR309; Bimiralisib free base.

IUPAC/Chemical Name: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

InChi Key: ADGGYDAFIHSYFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)

SMILES Code: NC1=NC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C(C(F)(F)F)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

 1: Big Hopes with Small Molecules - PIQUR Therapeutics AG is aiming to Turn
Cancer into a Manageable Disease. Chimia (Aarau). 2014 Dec;68(12):891-2. doi:
10.2533/chimia.2014.891. PubMed PMID: 26508614.