Mirfentanil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126105

CAS#: 117523-47-4

Description: Mirfentanil was developed as CNS analgesic with a short duration of action.

Chemical Structure

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Mirfentanil
CAS# 117523-47-4
Instruction

Theoretical Analysis

MedKoo Cat#: 126105
Name: Mirfentanil
CAS#: 117523-47-4
Chemical Formula: C22H24N4O2
Exact Mass: 376.19
Molecular Weight: 376.460
Elemental Analysis: C, 70.19; H, 6.43; N, 14.88; O, 8.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MIRFENTANYL; Mirfentanil;

IUPAC/Chemical Name: N-(1-phenethylpiperidin-4-yl)-N-(pyrazin-2-yl)furan-2-carboxamide

InChi Key: BJZZDOLVVLWFHN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N4O2/c27-22(20-7-4-16-28-20)26(21-17-23-11-12-24-21)19-9-14-25(15-10-19)13-8-18-5-2-1-3-6-18/h1-7,11-12,16-17,19H,8-10,13-15H2

SMILES Code: O=C(N(C1CCN(CCC2=CC=CC=C2)CC1)C3=NC=CN=C3)C4=CC=CO4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 376.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Robertson TBR, Gilbert N, Sutcliffe OB, Mewis RE. Hyperpolarisation of
Mirfentanil by SABRE in the Presence of Heroin. Chemphyschem. 2021 Jun
4;22(11):1059-1064. doi: 10.1002/cphc.202100165. Epub 2021 May 11. PMID:
33871116.

2: France CP, Winger G, Medzihradsky F, Seggel MR, Rice KC, Woods JH.
Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid
and nonopioid effects. J Pharmacol Exp Ther. 1991 Aug;258(2):502-10. PMID:
1650830.

3: Carr DJ, Brockunier LL, Scott M, Bagley JR, France CP. Mirfentanil
antagonizes morphine-induced suppression of splenic NK activity in mice.
Immunopharmacology. 1996 Aug;34(1):9-16. doi: 10.1016/0162-3109(95)00051-8.
PMID: 8880221.

4: Lemmens HJ, Egan TD, Fiset P, Stanski DR. Pharmacokinetic/dynamic assessment
in drug development: application to the investigational opioid mirfentanil.
Anesth Analg. 1995 Jun;80(6):1206-11. doi: 10.1097/00000539-199506000-00024.
PMID: 7762853.

5: Lelas S, Gerak LR, Landers LK, Brandt MR, Bagley JR, Brockunier LL, France
CP. Pharmacological profile of a deuterium-substituted mirfentanil derivative,
OHM10579, in rhesus monkeys. Pharmacol Biochem Behav. 1998 Jul;60(3):665-75.
doi: 10.1016/s0091-3057(98)00046-x. PMID: 9678650.

6: Egan JA, Nugent RP, Filer CN. Mirfentanil and A-4334: Tritiation at high
specific activity. Appl Radiat Isot. 2010 Jan;68(1):120-1. doi:
10.1016/j.apradiso.2009.10.002. Epub 2009 Oct 13. PMID: 19875301.

7: Gauthier CA, Bagley JR, Brockunier LL, France CP. Daily mirfentanil induces
(cross-) tolerance to the rate-decreasing effects of morphine and not
mirfentanil. Behav Pharmacol. 1999 Sep;10(5):543-7. doi:
10.1097/00008877-199909000-00012. PMID: 10780260.

8: Buggé CJ, Tucker MD, Garcia DB, Kvalo LT, Wilhelm JA. Determination of
mirfentanil hydrochloride (A-3508.HCl) in human plasma by liquid chromatography-
mass spectrometry. J Pharm Biomed Anal. 1993 Sep;11(9):809-15. doi:
10.1016/0731-7085(93)80073-a. PMID: 8218525.