Chlormethazole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126101

CAS#: 20354-26-1

Description: Chlormethazole (also known as Methazole) is an oxadiazolidine derivative and selective herbicide formerly used in Australia to control weeds in onions.

Chemical Structure

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Chlormethazole
CAS# 20354-26-1
Instruction

Theoretical Analysis

MedKoo Cat#: 126101
Name: Chlormethazole
CAS#: 20354-26-1
Chemical Formula: C9H6Cl2N2O3
Exact Mass: 259.98
Molecular Weight: 261.058
Elemental Analysis: C, 41.41; H, 2.32; Cl, 27.16; N, 10.73; O, 18.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Methazole; Probe; 20354-26-1; Oxydiazol; Bioxone

IUPAC/Chemical Name: 2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione

InChi Key: LRUUNMYPIBZBQH-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H6Cl2N2O3/c1-12-8(14)13(16-9(12)15)5-2-3-6(10)7(11)4-5/h2-4H,1H3

SMILES Code: CN1C(=O)ON(C1=O)C2=CC(Cl)=C(Cl)C=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 261.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gregg E, Akhter I. Chlormethiazole abuse. Br J Psychiatry. 1979
Jun;134:627-9. doi: 10.1192/bjp.134.6.627. PMID: 476374.

2: McInnes GT. Chlormethiazole and alcohol: a lethal cocktail. Br Med J (Clin
Res Ed). 1987 Mar 7;294(6572):592. doi: 10.1136/bmj.294.6572.592. PMID: 3103815;
PMCID: PMC1245638.

3: Illingworth RN, Stewart MJ, Jarvie DR. Poisoning with chlormethiazole. Br Med
J. 1980 Jan 5;280(6206):47-8. doi: 10.1136/bmj.280.6206.47-b. PMID: 7357271;
PMCID: PMC1600485.

4: McInnes GT, Young RE. Poisoning with chlormethiazole. Br Med J. 1980 Jan
5;280(6206):47. doi: 10.1136/bmj.280.6206.47-a. PMID: 7357270; PMCID:
PMC1600521.

5: Wilby MJ, Hutchinson PJ. The pharmacology of chlormethiazole: a potential
neuroprotective agent? CNS Drug Rev. 2004 Winter;10(4):281-94. doi:
10.1111/j.1527-3458.2004.tb00028.x. PMID: 15592579; PMCID: PMC6741715.

6: Glatt MM. Chlormethiazole addiction. Br Med J. 1978 Sep 23;2(6141):894-5.
doi: 10.1136/bmj.2.6141.894-b. PMID: 709111; PMCID: PMC1607962.

7: STALLWORTHY J. TO-DAY'S DRUGS. CHLORMETHIAZOLE. Br Med J. 1964 Jul
18;2(5402):171. PMID: 14150896; PMCID: PMC1816116.

8: Fulton B, Park GR. Intravenous chlormethiazole. Br J Hosp Med. 1992 Dec
2-1993 Jan 5;48(11):742-7. PMID: 1467819.

9: Oswald I, Adam K. Chlormethiazole and temazepam. Br Med J. 1980 Mar
22;280(6217):860-1. doi: 10.1136/bmj.280.6217.860-b. PMID: 6102879; PMCID:
PMC1601027.

10: Briggs RS, Castleden M, Kraft CA. Chlormethiazole and temazepam. Br Med J.
1980 Apr 19;280(6221):1085-6. doi: 10.1136/bmj.280.6221.1085-c. PMID: 6104528;
PMCID: PMC1601219.