T-2 toxin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126050

CAS#: 21259-20-1

Description: T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium.

Chemical Structure

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T-2 toxin
CAS# 21259-20-1
Instruction

Theoretical Analysis

MedKoo Cat#: 126050
Name: T-2 toxin
CAS#: 21259-20-1
Chemical Formula: C24H34O9
Exact Mass: 466.22
Molecular Weight: 466.527
Elemental Analysis: C, 61.79; H, 7.35; O, 30.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: T-2 TOXIN; T2 Toxin; T2-Trichothecene; Mycotoxin T-2; Insariotoxin; Isaritoxin; T-2 mycotoxin; Fusariotoxine T2; Fusariotoxin T-2; Toxin T2; Fusariotoxin T 2

IUPAC/Chemical Name: (2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-4'-acetoxy-5a'-(acetoxymethyl)-3'-hydroxy-5',8'-dimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl 3-methylbutanoate

InChi Key: BXFOFFBJRFZBQZ-QYWOHJEZSA-N

InChi Code: InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1

SMILES Code: [H][C@@]12O[C@]3([H])C=C(C)[C@H](C[C@]3(COC(C)=O)[C@@](C)([C@H](OC(C)=O)[C@H]1O)[C@]24CO4)OC(=O)CC(C)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 466.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Song W, Wang Y, Huang T, Liu Y, Chen F, Chen Y, Jiang Y, Zhang C, Yang X. T-2
toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism
and detoxification. Environ Pollut. 2023 Aug 1;330:121784. doi:
10.1016/j.envpol.2023.121784. Epub 2023 May 9. PMID: 37169237.

2: Janik E, Niemcewicz M, Podogrocki M, Ceremuga M, Stela M, Bijak M. T-2 Toxin-
The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and
Decontamination Strategies. Molecules. 2021 Nov 14;26(22):6868. doi:
10.3390/molecules26226868. PMID: 34833960; PMCID: PMC8618548.

3: Dai C, Das Gupta S, Wang Z, Jiang H, Velkov T, Shen J. T-2 toxin and its
cardiotoxicity: New insights on the molecular mechanisms and therapeutic
implications. Food Chem Toxicol. 2022 Sep;167:113262. doi:
10.1016/j.fct.2022.113262. Epub 2022 Jul 2. PMID: 35792220.

4: Li SJ, Zhang G, Xue B, Ding Q, Han L, Huang JC, Wu F, Li C, Yang C. Toxicity
and detoxification of T-2 toxin in poultry. Food Chem Toxicol. 2022
Nov;169:113392. doi: 10.1016/j.fct.2022.113392. Epub 2022 Aug 28. PMID:
36044934.

5: Yang X, Liu P, Cui Y, Xiao B, Liu M, Song M, Huang W, Li Y. Review of the
Reproductive Toxicity of T-2 Toxin. J Agric Food Chem. 2020 Jan
22;68(3):727-734. doi: 10.1021/acs.jafc.9b07880. Epub 2020 Jan 8. PMID:
31895560.

6: Wu Q, Qin Z, Kuca K, You L, Zhao Y, Liu A, Musilek K, Chrienova Z, Nepovimova
E, Oleksak P, Wu W, Wang X. An update on T-2 toxin and its modified forms:
metabolism, immunotoxicity mechanism, and human exposure assessment. Arch
Toxicol. 2020 Nov;94(11):3645-3669. doi: 10.1007/s00204-020-02899-9. Epub 2020
Sep 10. PMID: 32910237.

7: Li Y, Wang Z, Beier RC, Shen J, De Smet D, De Saeger S, Zhang S. T-2 toxin, a
trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods.
J Agric Food Chem. 2011 Apr 27;59(8):3441-53. doi: 10.1021/jf200767q. Epub 2011
Mar 25. PMID: 21417259.

8: Wang C, He J, Jin H, Xiao H, Peng S, Xie J, Zhang L, Guo J. T-2 toxin induces
cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1.
Chemosphere. 2023 Nov;341:140087. doi: 10.1016/j.chemosphere.2023.140087. Epub
2023 Sep 5. PMID: 37678596.

9: Li J, Wang Y, Deng Y, Wang X, Wu W, Nepovimova E, Wu Q, Kuca K. Toxic
mechanisms of the trichothecenes T-2 toxin and deoxynivalenol on protein
synthesis. Food Chem Toxicol. 2022 Jun;164:113044. doi:
10.1016/j.fct.2022.113044. Epub 2022 Apr 19. PMID: 35452771.

10: Zhang J, Wang P, Song M, Zhang X, Huo S, Du J, Li B, Cao Z, Li Y. T-2 toxin
inhibits osteoblastic differentiation and mineralization involving mutual
regulation between Wnt signaling pathway and autophagy. Chem Biol Interact. 2023
Jan 5;369:110266. doi: 10.1016/j.cbi.2022.110266. Epub 2022 Nov 17. PMID:
36402210.