WDR5-MYC Probe 12
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MedKoo CAT#: 125915

CAS#: N/A

Description: WDR5-MYC probe 12 is an inhibitor of the protein-protein interaction between the master transcription factor Myc and WD repeat domain 5 (WDR5; IC50 = 0.39 µM)

Chemical Structure

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WDR5-MYC Probe 12
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 125915
Name: WDR5-MYC Probe 12
CAS#: N/A
Chemical Formula: C25H18F3N3O4S
Exact Mass: 513.10
Molecular Weight: 513.491
Elemental Analysis: C, 58.48; H, 3.53; F, 11.10; N, 8.18; O, 12.46; S, 6.24

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
10mg USD 950 2 Weeks
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Synonym: WDR5-MYC Probe 12; WDR5-MYC; WDR5MYC; WDR5 MYC

IUPAC/Chemical Name: 3',5'-difluoro-4'-((6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamido)methyl)-[1,1'-biphenyl]-3-sulfonyl fluoride

InChi Key: KCMSIHHWMOTDFN-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H18F3N3O4S/c1-15-10-23(32)24(30-31(15)18-7-3-2-4-8-18)25(33)29-14-20-21(26)12-17(13-22(20)27)16-6-5-9-19(11-16)36(28,34)35/h2-13H,14H2,1H3,(H,29,33)

SMILES Code: CC(N1C2=CC=CC=C2)=CC(C(C(NCC3=C(F)C=C(C4=CC(S(F)(=O)=O)=CC=C4)C=C3F)=O)=N1)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 513.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Ding J, Liu L, Chiang YL, Zhao M, Liu H, Yang F, Shen L, Lin Y, Deng H, Gao J, Sage DR, West L, Llamas LA, Hao X, Kawatkar S, Li E, Jain RK, Tallarico JA, Canham SM, Wang H. Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J Med Chem. 2023 Jun 22;66(12):8310-8323. doi: 10.1021/acs.jmedchem.3c00787. Epub 2023 Jun 12. PMID: 37307526.