SK-124

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125896

CAS#: 2760404-50-8

Description: SK-124 is a SIK inhibitor.

Chemical Structure

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SK-124
CAS# 2760404-50-8
Instruction

Theoretical Analysis

MedKoo Cat#: 125896
Name: SK-124
CAS#: 2760404-50-8
Chemical Formula: C23H22N6O3
Exact Mass: 430.18
Molecular Weight: 430.468
Elemental Analysis: C, 64.18; H, 5.15; N, 19.52; O, 11.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SK-124; SK124; SK 124

IUPAC/Chemical Name: 2-(2,6-dimethoxy-4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)phenyl)-5-ethyl-1,3,4-oxadiazole

InChi Key: VOYZWDQJVPQGCO-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N6O3/c1-5-21-26-27-23(32-21)22-18(30-3)8-15(9-19(22)31-4)17-12-24-20-10-14(6-7-29(17)20)16-11-25-28(2)13-16/h6-13H,5H2,1-4H3

SMILES Code: COC1=CC(C2=CN=C3N2C=CC(C4=CN(C)N=C4)=C3)=CC(OC)=C1C(O5)=NN=C5CC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U,
Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN.
Structure-based design of selective, orally available salt-inducible kinase
inhibitors that stimulate bone formation in mice. Proc Natl Acad Sci U S A. 2022
Dec 13;119(50):e2214396119. doi: 10.1073/pnas.2214396119. Epub 2022 Dec 6. PMID:
36472957; PMCID: PMC9897432.

2: Meyer MB, Benkusky NA, Lee SM, Yoon SH, Mannstadt M, Wein MN, Pike JW. Rapid
genomic changes by mineralotropic hormones and kinase SIK inhibition drive
coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules. J Biol Chem.
2022 Nov;298(11):102559. doi: 10.1016/j.jbc.2022.102559. Epub 2022 Sep 30. PMID:
36183832; PMCID: PMC9637672.