XPW1
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MedKoo CAT#: 125670

CAS#: 2700286-66-2

Description: XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.

Chemical Structure

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XPW1
CAS# 2700286-66-2
Instruction

Theoretical Analysis

MedKoo Cat#: 125670
Name: XPW1
CAS#: 2700286-66-2
Chemical Formula: C36H39ClFN7O2
Exact Mass: 655.28
Molecular Weight: 656.200
Elemental Analysis: C, 65.89; H, 5.99; Cl, 5.40; F, 2.90; N, 14.94; O, 4.88

Price and Availability

Size Price Availability Quantity
10mg USD 750 2 Weeks
25mg USD 1250 2 Weeks
50mg USD 2250 2 Weeks
100mg USD 3650 2 Weeks
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Synonym: XPW1; XPW-1; XPW 1

IUPAC/Chemical Name: N-((1r,4r)-4-((5'-chloro-6-((3-fluorobenzyl)amino)-[2,4'-bipyridin]-2'-yl)amino)cyclohexyl)-4-((E)-4-(dimethylamino)but-2-enamido)benzamide

InChi Key: DCNDHFXVQIDEQS-QYBHMFEJSA-N

InChi Code: InChI=1S/C36H39ClFN7O2/c1-45(2)19-5-10-35(46)42-28-13-11-25(12-14-28)36(47)43-29-17-15-27(16-18-29)41-34-21-30(31(37)23-40-34)32-8-4-9-33(44-32)39-22-24-6-3-7-26(38)20-24/h3-14,20-21,23,27,29H,15-19,22H2,1-2H3,(H,39,44)(H,40,41)(H,42,46)(H,43,47)/b10-5+/t27-,29-

SMILES Code: O=C(N[C@H]1CC[C@H](NC2=NC=C(Cl)C(C3=NC(NCC4=CC=CC(F)=C4)=CC=C3)=C2)CC1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 656.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Kuang Z, Guo K, Cao Y, Jiang M, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T, Liu W, Fang M. The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer. 2023 Oct 26. doi: 10.1038/s41416-023-02464-y. Epub ahead of print. PMID: 37884683.