Fhbg F-18

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125483

CAS#: 206067-82-5

Description: Fhbg F-18, also named as18F-FHBG, is a fluorine-18-labeled acycloguanosine derivative substrate for herpes simplex virus type-1 thymidine kinase (HSV1-tk).

Chemical Structure

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Fhbg F-18
CAS# 206067-82-5
Instruction

Theoretical Analysis

MedKoo Cat#: 125483
Name: Fhbg F-18
CAS#: 206067-82-5
Chemical Formula: C10H1418FN5O2
Exact Mass: 254.12
Molecular Weight: 254.260
Elemental Analysis: C, 47.24; H, 5.55; F, 7.08; N, 27.55; O, 12.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 18F-Fhbg; Fhbg F-18; ((Sup 18)F)-fhbg; (18F)-Fhbg; HAF26OMU2K

IUPAC/Chemical Name: 2-amino-9-(4-(fluoro-18F)-3-(hydroxymethyl)butyl)-1,9-dihydro-6H-purin-6-one

InChi Key: CEIVUGLBKBWVAE-KXMUYVCJSA-N

InChi Code: InChI=1S/C10H14FN5O2/c11-3-6(4-17)1-2-16-5-13-7-8(16)14-10(12)15-9(7)18/h5-6,17H,1-4H2,(H3,12,14,15,18)/i11-1

SMILES Code: NC1=NC2=C(N=CN2CCC(CO)C[18F])C(=O)N1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 254.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Salabert AS, Vaysse L, Beaurain M, Alonso M, Arribarat G, Lotterie JA,
Loubinoux I, Tafani M, Payoux P. Imaging grafted cells with [18F]FHBG using an
optimized HSV1-TK mammalian expression vector in a brain injury rodent model.
PLoS One. 2017 Sep 19;12(9):e0184630. doi: 10.1371/journal.pone.0184630. PMID:
28926581; PMCID: PMC5604981.

2: Min JJ, Iyer M, Gambhir SS. Comparison of [18F]FHBG and [14C]FIAU for imaging
of HSV1-tk reporter gene expression: adenoviral infection vs stable
transfection. Eur J Nucl Med Mol Imaging. 2003 Nov;30(11):1547-60. doi:
10.1007/s00259-003-1238-6. Epub 2003 Jul 10. PMID: 14579096.

3: Green LA, Nguyen K, Berenji B, Iyer M, Bauer E, Barrio JR, Namavari M,
Satyamurthy N, Gambhir SS. A tracer kinetic model for 18F-FHBG for quantitating
herpes simplex virus type 1 thymidine kinase reporter gene expression in living
animals using PET. J Nucl Med. 2004 Sep;45(9):1560-70. PMID: 15347725.

4: Chang CW, Lin M, Wu SY, Hsieh CH, Liu RS, Wang SJ, Huang KL, Chen CH, Wang
HE. A high yield robotic synthesis of
9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and
9-[3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F] FHPG) for gene
expression imaging. Appl Radiat Isot. 2007 Jan;65(1):57-63. doi:
10.1016/j.apradiso.2006.06.005. Epub 2006 Aug 17. PMID: 16916606.

5: Tang G, Tang X, Li H, Wang M, Li B, Liang M, Wu H, Wang Q. A simplified one-
pot automated synthesis of [18F]FHBG for imaging reporter gene expression. Nucl
Med Commun. 2010 Mar;31(3):211-6. doi: 10.1097/MNM.0b013e328334bfe2. PMID:
20032804.

6: Shiue GG, Shiue CY, Lee RL, MacDonald D, Hustinx R, Eck SL, Alavi AA. A
simplified one-pot synthesis of
9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and
9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy. Nucl
Med Biol. 2001 Oct;28(7):875-83. doi: 10.1016/s0969-8051(01)00253-0. PMID:
11578910.

7: Alauddin MM, Conti PS. Synthesis and preliminary evaluation of
9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG): a new potential
imaging agent for viral infection and gene therapy using PET. Nucl Med Biol.
1998 Apr;25(3):175-80. doi: 10.1016/s0969-8051(97)00160-1. PMID: 9620620.

8: Yaghoubi SS, Couto MA, Chen CC, Polavaram L, Cui G, Sen L, Gambhir SS.
Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging
herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's
expression. J Nucl Med. 2006 Apr;47(4):706-15. PMID: 16595506.

9: Leung K. 9-(4-[18F]Fluoro-3-hydroxymethylbutyl)guanine. 2005 Jan
24 [updated 2005 Feb 23]. In: Molecular Imaging and Contrast Agent Database
(MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information
(US); 2004–2013. PMID: 20641753.

10: Li X, Yin G, Ji W, Liu J, Zhang Y, Wang J, Zhu X, Zhu L, Dai D, Ma W, Xu W.
18F-FHBG PET-CT Reporter Gene Imaging of Adoptive CIK Cell Transfer
Immunotherapy for Breast Cancer in a Mouse Model. Onco Targets Ther. 2020 Nov
13;13:11659-11668. doi: 10.2147/OTT.S271657. PMID: 33223839; PMCID: PMC7671474.