Mivobulin free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205980

CAS#: 122332-18-7 (free base)

Description: Mivobulin, also known as CI-980, is a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis.


Price and Availability

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10mg
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100mg
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1g
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25mg
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200mg
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2g
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50mg
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500mg
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5g
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Mivobulin isethionate is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205980
Name: Mivobulin free base
CAS#: 122332-18-7 (free base)
Chemical Formula: C17H19N5O2
Exact Mass: 325.1539
Molecular Weight: 325.372
Elemental Analysis: C, 62.75; H, 5.89; N, 21.52; O, 9.83


Synonym: Mivobulin free base; CI-980; NSC-613863; NSC-635370; NSC-613862; NSC-350386; CI980; NSC613863; NSC635370; NSC613862; NSC350386.

IUPAC/Chemical Name: (S)-ethyl (5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate

SMILES Code: O=C(OCC)NC1=CC2=C(C(N)=N1)N=C(C3=CC=CC=C3)[C@H](C)N2


Technical Data

Appearance:
Solid powder

Purity:
>98%

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  Related CAS#
122332-18-7 (Mivobulin free base)
126268-81-3 (Mivobulin Isethionate)
 
 
 


References

1: Kunschner LJ, Fine H, Hess K, Jaeckle K, Kyritsis AP, Yung WK. CI-980 for the treatment of recurrent or progressive malignant gliomas: national central nervous system consortium phase I-II evaluation of CI-980. Cancer Invest. 2002;20(7-8):948-54. PubMed PMID: 12449727.

2: Thomas JP, Moore T, Kraut EH, Balcerzak SP, Galloway S, Vandre DD; Ohio State University Phase II Research Consortium Study.. A phase II study of CI-980 in previously untreated extensive small cell lung cancer: an Ohio State University phase II research consortium study. Cancer Invest. 2002;20(2):192-8. PubMed PMID: 11901539.

3: Whitehead RP, Unger JM, Flaherty LE, Eckardt JR, Taylor SA, Didolkar MS, Samlowski W, Sondak VK. Phase II trial of CI-980 in patients with disseminated malignant melanoma and no prior chemotherapy. A Southwest Oncology Group study. Invest New Drugs. 2001;19(3):239-43. PubMed PMID: 11561681.

4: Ryan CW, Shulman KL, Richards JM, Kugler JW, Sosman JA, Ansari RH, Vokes EE, Vogelzang NJ. CI-980 in advanced melanoma and hormone refractory prostate cancer. Invest New Drugs. 2000 May;18(2):187-91. PubMed PMID: 10857996.

5: Bernstein ML, Baruchel S, Devine S, Markoglou N, Wainer IW, Williams M, Blaney S, Moghrabi A, Winick N, Vietti T. Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study. J Pediatr Hematol Oncol. 1999 Nov-Dec;21(6):494-500. PubMed PMID: 10598660.

6: Patel SR, Burgess MA, Papadopolous NE, Sidhu G, Gray R, Plager C, Jenkins J, Benjamin RS. Phase II study of CI-980 (NSC 635370) in patients with previously treated advanced soft-tissue sarcomas. Invest New Drugs. 1998;16(1):87-92. PubMed PMID: 9740549.

7: Kudelka AP, Hasenburg A, Verschraegen CF, Edwards CL, Meyers CA, Varma D, Freedman RS, Forman A, Conrad CA, Grove W, Grothey A, Kavanagh JJ. Phase II study of i.v. CI-980 in patients with advanced platinum refractory epithelial ovarian carcinoma. Anticancer Drugs. 1998 Jun;9(5):405-9. PubMed PMID: 9660537.

8: Pazdur R, Meyers C, Diaz-Canton E, Abbruzzese JL, Patt Y, Grove W, Ajani J. Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity. Am J Clin Oncol. 1997 Dec;20(6):573-6. PubMed PMID: 9391543.

9: Markoglou N, Wainer IW. Determination of the anticancer agent CI-980 in plasma by achiral liquid chromatography on a Pirkle-type stationary phase. J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):493-7. PubMed PMID: 9210458.

10: Wright J, Ho PT, Phillips PH, Cheson BD. Clinical Trials. Referral resource Clinical trials using CI-980 (mivobulin isethionate). Oncology (Williston Park). 1997 May;11(5):643-4. PubMed PMID: 9159791.

11: Meyers CA, Kudelka AP, Conrad CA, Gelke CK, Grove W, Pazdur R. Neurotoxicity of CI-980, a novel mitotic inhibitor. Clin Cancer Res. 1997 Mar;3(3):419-22. PubMed PMID: 9815700.

12: Rowinsky EK, Long GS, Noe DA, Grochow LB, Bowling MK, Sartorius SE, Donehower RC. Phase I and pharmacological study of CI-980, a novel synthetic antimicrotubule agent. Clin Cancer Res. 1997 Mar;3(3):401-7. PubMed PMID: 9815698.

13: Sklarin NT, Lathia CD, Benson L, Grove WR, Thomas S, Roca J, Einzig AI, Wiernik PH. A phase I trial and pharmacokinetic evaluation of CI-980 in patients with advanced solid tumors. Invest New Drugs. 1997;15(3):235-46. PubMed PMID: 9387046.

14: Pérez O, Valenzuela C, Delpón E, Tamargo J. Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles. Br J Pharmacol. 1997 Jan;120(2):187-92. PubMed PMID: 9117108; PubMed Central PMCID: PMC1564362.

15: Barbier P, Peyrot V, Dumortier C, D'Hoore A, Rener GA, Engelborghs Y. Kinetics of association and dissociation of two enantiomers, NSC 613863 (R)-(+) and NSC 613862 (S)-(-) (CI 980), to tubulin. Biochemistry. 1996 Feb 13;35(6):2008-15. PubMed PMID: 8639685.

16: Hook KE, Przybranowski SA, Leopold WR. Cellular transport of CI-980. Invest New Drugs. 1996;14(4):341-7. PubMed PMID: 9157068.

17: Bullen WW, Whitfield LR, Walter GA, Brodfuehrer JI. High-performance liquid chromatographic assay for CI-980, a novel 1-deaza-7,8-dihydropteridine anticancer agent, in human plasma and urine. J Chromatogr B Biomed Appl. 1995 Jun 9;668(1):141-51. PubMed PMID: 7550971.

18: Chevalier P, Kuznetsov V, Robinson RB, Rosen MR. Tubulin binding agent CI-980 has positive inotropic and local anesthetic actions. J Cardiovasc Pharmacol. 1994 Jun;23(6):944-51. PubMed PMID: 7523787.

19: de Ines C, Leynadier D, Barasoain I, Peyrot V, Garcia P, Briand C, Rener GA, Temple C Jr. Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863. Cancer Res. 1994 Jan 1;54(1):75-84. PubMed PMID: 8261466.

20: MacDonald JR, Pegg DG. Extravasation injury potential of CI-980, a novel synthetic mitotic inhibitor. Cancer Chemother Pharmacol. 1993;32(5):365-7. PubMed PMID: 8339386.