CBiPES HCl | CAS#856702-40-4 | allosteric modulator | mGlu2 receptor

CBiPES HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125225

CAS#: 856702-40-4

Description: CBiPES HCl is a selective positive allosteric modulator of the mGlu2 receptor.

Chemical Structure

CBiPES HCl

CAS# 856702-40-4

Instruction

Theoretical Analysis

MedKoo Cat#: 125225
Name: CBiPES HCl
CAS#: 856702-40-4
Chemical Formula: C21H20ClN3O2S
Exact Mass: 413.10
Molecular Weight: 413.920
Elemental Analysis: C, 60.94; H, 4.87; Cl, 8.56; N, 10.15; O, 7.73; S, 7.75

Price and Availability

Size	Price	Availability
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3850	2 Weeks
2g	USD 5950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: CBiPES hydrochloride; 856702-40-4; DL3XSQ69E9; CBiPES (hydrochloride); UNII-DL3XSQ69E9

IUPAC/Chemical Name: N-(4'-cyano-[1,1'-biphenyl]-3-yl)-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride

InChi Key: QKUHSVQWWZBAKM-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H

SMILES Code: O=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Frouni I, Kwan C, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D,
Gourdon JC, Huot P. Effect of the mGlu₂ positive allosteric modulator
CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-
lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81. doi:
10.1007/s00702-020-02287-8. Epub 2021 Jan 3. PMID: 33392826.

2: Benvenga MJ, Chaney SF, Baez M, Britton TC, Hornback WJ, Monn JA, Marek GJ.
Metabotropic Glutamate₂ Receptors Play a Key Role in Modulating Head
Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018
Mar 15;9:208. doi: 10.3389/fphar.2018.00208. PMID: 29599719; PMCID: PMC5862811.

3: Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic
glutamate receptors reduces behavioral and electrographic correlates of
pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb;108(2):171-81.
doi: 10.1016/j.eplepsyres.2013.10.009. Epub 2013 Nov 16. PMID: 24305700; PMCID:
PMC4378620.

4: Johnson PL, Fitz SD, Engleman EA, Svensson KA, Schkeryantz JM, Shekhar A.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent
sodium lactate-induced panic-like response in panic-vulnerable rats. J
Psychopharmacol. 2013 Feb;27(2):152-61. doi: 10.1177/0269881112454230. Epub 2012
Aug 21. PMID: 22914798; PMCID: PMC4300988.

5: Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, McKinzie
DL, Nisenbaum ES, Tizzano JP, Schoepp DD. Metabotropic glutamate 2 receptor
potentiators: receptor modulation, frequency-dependent synaptic activity, and
efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology
(Berl). 2005 Apr;179(1):271-83. doi: 10.1007/s00213-004-2099-9. Epub 2005 Feb
17. PMID: 15717213.

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