Rabusertib (LY2603618)
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 201794

CAS#: 911222-45-2

Description: Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3850
Size
Price

25mg
USD 250
200mg
USD 1150
2g
USD 4950
Size
Price

50mg
USD 450
500mg
USD 2450
5g
Ask price

Rabusertib (LY2603618), purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international). Note: the estimated shipping out time for order > 1g may be 2 weeks.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 201794
Name: Rabusertib (LY2603618)
CAS#: 911222-45-2
Chemical Formula: C18H22BrN5O3
Exact Mass: 435.0906
Molecular Weight: 436.3
Elemental Analysis: C, 49.55; H, 5.08; Br, 18.31; N, 16.05; O, 11.00


Synonym: LY2603618; LY 2603618; LY-2603618; Rabusertib

IUPAC/Chemical Name: (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea.

SMILES Code: CC1=C(Br)C=C(C(OC[C@@H]2CNCCO2)=C1)NC(NC3=NC=C(N=C3)C)=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
 


References

1. Compositions of Chk1 kinase inhibitor for cancer treatment By Colvin, Anita A.; Koppenol, Sandy; Wisdom, Wendy A.  From PCT Int. Appl. (2008), WO 2008067027 A2 20080605.