KX-01
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205927

CAS#: 897016-82-9

Description: KX-01 is the first clinical Src inhibitor of the novel peptidomimetic class that targets the peptide substrate site of Src providing more specificity toward Src kinase.


Price and Availability

Size
Price

10mg
USD 300
Size
Price

50mg
USD 800
Size
Price

100mg
USD 1400

KX-01, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 205927
Name: KX-01
CAS#: 897016-82-9
Chemical Formula: C25H27N3O3
Exact Mass: 417.20524
Molecular Weight: 417.5
Elemental Analysis: C, 71.92; H, 6.52; N, 10.06; O, 11.50


Synonym: KX01., KX-01, KX 01

IUPAC/Chemical Name: N-benzyl-5-(4-(2-morpholinoethoxy)phenyl)picolinamide

InChi Key: XAGHFOWYLRVALA-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H27N3O3/c29-25(27-18-20-4-2-1-3-5-20)24-11-8-22(19-26-24)21-6-9-23(10-7-21)31-17-14-28-12-15-30-16-13-28/h1-11,19H,12-18H2,(H,27,29)

SMILES Code: O=C(NCC1=CC=CC=C1)C2=NC=C(C3=CC=C(OCCN4CCOCC4)C=C3)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98%

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Anbalagan M, Ali A, Jones RK, Marsden CG, Sheng M, Carrier L, Bu Y, Hangauer D, Rowan BG. Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Mol Cancer Ther. 2012 Sep;11(9):1936-47. doi: 10.1158/1535-7163.MCT-12-0146. Epub 2012 Jul 10. PubMed PMID: 22784709; PubMed Central PMCID: PMC3462004.

2: Fallah-Tafti A, Foroumadi A, Tiwari R, Shirazi AN, Hangauer DG, Bu Y, Akbarzadeh T, Parang K, Shafiee A. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem. 2011 Oct;46(10):4853-8. doi: 10.1016/j.ejmech.2011.07.050. Epub 2011 Aug 4. PubMed PMID: 21852023.