PF-07220060
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207196

CAS#: 2380321-51-5

Description: PF-07220060 is a novel potent oral CDK4-selective inhibitor. PF-07220060 is under clinical development by Pfizer and currently in Phase I for Metastatic Breast Cancer.

Chemical Structure

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PF-07220060
CAS# 2380321-51-5
Instruction

Theoretical Analysis

MedKoo Cat#: 207196
Name: PF-07220060
CAS#: 2380321-51-5
Chemical Formula: C22H27ClFN5O3
Exact Mass: 463.18
Molecular Weight: 463.938
Elemental Analysis: C, 56.96; H, 5.87; Cl, 7.64; F, 4.10; N, 15.10; O, 10.35

Price and Availability

Size Price Availability Quantity
25mg USD 750 2 Weeks
50mg USD 1150 2 Weeks
100mg USD 1750 2 Weeks
200mg USD 2750 2 Weeks
500mg USD 5450 2 Weeks
1g USD 8650 2 Weeks
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Synonym: PF-07220060; PF 07220060; PF07220060;

IUPAC/Chemical Name: (3S,4R)-4-((5-chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol

InChi Key: QYJLBHRAPDJOSO-NVXWUHKLSA-N

InChi Code: InChI=1S/C22H27ClFN5O3/c1-11(2)29-16-8-12(7-14(24)19(16)27-20(29)22(3,4)31)18-13(23)9-25-21(28-18)26-15-5-6-32-10-17(15)30/h7-9,11,15,17,30-31H,5-6,10H2,1-4H3,(H,25,26,28)/t15-,17-/m1/s1

SMILES Code: CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](COCC4)O)=NC=C3Cl)=CC(F)=C2N=C1C(C)(O)C)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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