Famitinib

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205935

CAS#: 1044040-56-3 (free base)

Description: Famitinib is a novel multi-targeted receptor tyrosine kinase inhibitor under development for cancer treatment. Famitinib is a structural analogue of sunitinib, is a novel and potent multi-targeted RTK inhibitor that is currently undergoing phase II clinical trials in China for the treatment of renal cell carcinoma, gastrointestinal stromal tumours, pancreatic cancer, and nasopharyngeal carcinoma. Compared with sunitinib, famitinib exhibits superior inhibition activities against multiple RTKs.


Price and Availability

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Famitinib is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205935
Name: Famitinib
CAS#: 1044040-56-3 (free base)
Chemical Formula: C23H27FN4O2
Exact Mass: 410.2118
Molecular Weight: 410.48
Elemental Analysis: C, 67.30; H, 6.63; F, 4.63; N, 13.65; O, 7.80


Related CAS #: 1044040-56-3 (free base)   1256377-67-9 (L-malate)    

Synonym: Famitinib; SHR1020; SHR-1020; SHR 1020.

IUPAC/Chemical Name: (Z)-5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one

InChi Key: GKEYKDOLBLYGRB-LGMDPLHJSA-N

InChi Code: InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-

SMILES Code: O=C1C2=C(NC(/C=C3C(NC4=C\3C=C(F)C=C4)=O)=C2C)CCN1CCN(CC)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  Related CAS#
1044040-56-3 (Famitinib)
1256377-67-9 (Famitinib L-Malate)

Famitinib is a Me-Too drug of Sunitinib, which chemical structures are shown as the following:


References

1: Xie C, Zhou J, Guo Z, Diao X, Gao Z, Zhong D, Jiang H, Zhang L, Chen X. Metabolism and Bioactivation of Famitinib, a Novel Inhibitor of Receptor Tyrosine Kinase, in Cancer Patients. Br J Pharmacol. 2012 Nov 6. doi: 10.1111/bph.12047. [Epub ahead of print] PubMed PMID: 23126373.