MMV008416

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MedKoo CAT#: 130533

CAS#: MMV008416

Description: MMV008416 is an inhibitor of methionine aminopeptidases, type I (MetAp1) from Rickettsia prowazekii (RpMetAp1).

Chemical Structure

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MMV008416
CAS# MMV008416
Instruction

Theoretical Analysis

MedKoo Cat#: 130533
Name: MMV008416
CAS#: MMV008416
Chemical Formula: C15H20N2
Exact Mass: 228.16
Molecular Weight: 228.340
Elemental Analysis: C, 78.90; H, 8.83; N, 12.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MMV 008416, MMV-008416, GNF-Pf-3651, MLS000080101, SMR000036351, NSC766427, STK007737, AKOS005375852, NSC-766427

IUPAC/Chemical Name: 3-Ethyl-1-methyl-2-propylquinolin-4-imine

InChi Key: JAPBALWUJAIERZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H20N2/c1-4-8-13-11(5-2)15(16)12-9-6-7-10-14(12)17(13)3/h6-7,9-10,16H,4-5,8H2,1-3H3

SMILES Code: CCC1=C(CCC)N(C)C2=CC=CC=C2C1=N

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 228.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Sharma I, Chen C, Daraji D, Horn JR, Hagen TJ. Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box. Bioorg Med Chem Lett. 2023 May 1;87:129281. doi: 10.1016/j.bmcl.2023.129281. Epub 2023 Apr 7. PMID: 37031729.

2. Chirawurah JD, Ansah F, Nyarko PB, Duodu S, Aniweh Y, Awandare GA. Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):399-406. doi: 10.1016/j.ijpddr.2017.10.005. Epub 2017 Oct 16. PMID: 29128848; PMCID: PMC5683671.

3. Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936. Epub 2011 Nov 17. PMID: 22096101; PMCID: PMC3473092.