JNJ-78394355

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123389

CAS#: N/A

Description: JNJ-78394355 is a Mcl-1 inhibitor.

Chemical Structure

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JNJ-78394355
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 123389
Name: JNJ-78394355
CAS#: N/A
Chemical Formula: C40H44ClN5O5S
Exact Mass: 741.28
Molecular Weight: 742.330
Elemental Analysis: C, 64.72; H, 5.97; Cl, 4.78; N, 9.43; O, 10.78; S, 4.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JNJ-78394355; JNJ 78394355; JNJ78394355

IUPAC/Chemical Name: (Z)-15-chloro-21-(2-(2-methoxyethoxy)ethyl)-13,23,61-trimethyl-11H,21H,61H-10-oxa-4-thia-1(4,1)-indola-2(4,5),6(3,5)-dipyrazola-9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid

InChi Key: WREPOKHXPHVMBY-UHFFFAOYSA-N

InChi Code: InChI=1S/C40H44ClN5O5S/c1-25-36-33-13-12-32(41)38(36)37-26(2)42-46(15-17-50-19-18-49-4)34(37)24-52-23-29-22-30(44(3)43-29)11-10-27-20-28-8-5-6-9-31(28)35(21-27)51-16-7-14-45(33)39(25)40(47)48/h5-6,8-9,12-13,20-22H,7,10-11,14-19,23-24H2,1-4H3,(H,47,48)

SMILES Code: CC1=NN(CCOCCOC)C(CSC2)=C1C3=C(C4=CC=C3Cl)C(C)=C(C(O)=O)N4CCCOC5=CC(CCC6=CC2=NN6C)=CC7=C5C=CC=C7

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 742.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies
Fedor Romanov-Michailidis, Chien-Chi Hsiao, Lorenz M. Urner, Soufyan Jerhaoui, Michel Surkyn, Bradley Miller, Ann Vos, Maria Dominguez Blanco, Ruud Bueters, Petra Vinken, Mariette Bekkers, David Walker, Beth Pietrak, Werner Eyckmans, José Luís Dores-Sousa, Seong Joo Koo, William Lento, Marcus Bauser, Ulrike Philippar, and Frederik J. R. Rombouts
Journal of Medicinal Chemistry Article ASAP
DOI: 10.1021/acs.jmedchem.2c01953