CCW16
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130390

CAS#: N/A

Description: CCW16, which is the ligand for E3 ubiquitin ligase RNF4 (RING finger protein 4), is vital in the synthesis of protein degraders.

Chemical Structure

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CCW16
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130390
Name: CCW16
CAS#: N/A
Chemical Formula: C22H20ClNO3
Exact Mass: 381.11
Molecular Weight: 381.856
Elemental Analysis: C, 69.20; H, 5.28; Cl, 9.28; N, 3.67; O, 12.57

Price and Availability

Size Price Availability Quantity
100mg USD 553 2 Weeks
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Synonym: CCW16

IUPAC/Chemical Name: N-benzyl-2-chloro-N-(4-(4-methoxyphenoxy)phenyl)acetamide

InChi Key: DPADEQNOMBTITM-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20ClNO3/c1-26-19-11-13-21(14-12-19)27-20-9-7-18(8-10-20)24(22(25)15-23)16-17-5-3-2-4-6-17/h2-14H,15-16H2,1H3

SMILES Code: O=C(N(CC1=CC=CC=C1)C2=CC=C(OC3=CC=C(OC)C=C3)C=C2)CCl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 381.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13. PMID: 31059647; PMCID: PMC7422721.