Chiauranib

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206120

CAS#: NONE

Description: Chiauranib also known as orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. Upon oral administration, chiauranib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. These kinases are overexpressed by a variety of cancer cell types.


Price and Availability

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Price

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Chiauranib, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

No image available

Theoretical Analysis

MedKoo Cat#: 206120
Name: Chiauranib
CAS#: NONE
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:


Synonym: Chiauranib; CS2164; CS-2164; CS 2164.

IUPAC/Chemical Name: NONE


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Pepe M, Giardino C, Borsani G, Cardoso AC, Chiaudani G, Premazzi G, Rodari E, Zilioli E. Relationship between apparent optical properties and photosynthetic pigments in the sub-alpine Lake Iseo. Sci Total Environ. 2001 Mar 14;268(1-3):31-45. PubMed PMID: 11315745.

2: Domenegati E, Ceriana P, Chiaudani MG, Pagani F. [Anesthesiology problems for implant and explant of left ventricular Novacor systems]. Minerva Anestesiol. 1996 Jun;62(6):219-27. Italian. PubMed PMID: 9045100.

3: Ceriana P, Maurelli M, Locatelli A, Bianchi T, Chiaudani G, Domenegati E, Pagnin A. Pseudomyxoma of the right atrium in a patient with heparin-associated thrombocytopenia and antiphospholipid antibodies. J Cardiothorac Vasc Anesth. 1995 Jun;9(3):308-11. PubMed PMID: 7545451.

4: Domenegati E, Maurelli M, Chiaudani MG, Pagnin A, Rinaldi M. Management of anesthesia during dynamic cardiomyoplasty. J Clin Anesth. 1995 May;7(3):177-81. PubMed PMID: 7669304.

5: Ceriana P, Maurelli M, Pagani F, Locatelli A, Chiaudani G, Mazza MP, De Amici D, Bianchi T, Barzaghi N, Domenegati E, et al. [Drepanocytosis in patients undergoing heart surgery. Anesthesiologic problems]. Minerva Anestesiol. 1993 Mar;59(3):129-32. Italian. PubMed PMID: 8515853.

6: Ceriana P, Maurelli M, Locatelli A, Bianchi T, Chiaudani G, Mazza MP, Pagnin A. Sickle cell trait, open heart surgery, and SVO2. J Cardiothorac Vasc Anesth. 1992 Aug;6(4):514. PubMed PMID: 1498311.

7: Pagnin A, Ceriana P, Maurelli M, Locatelli A, Bertollo D, Mazza MP, Chiaudani G, Bianchi T. [Comparison between propofol and isoflurane in patients undergoing aorto-coronary bypass. Effect on systemic and coronary circulation]. Minerva Anestesiol. 1992 Jun;58(6):361-7. Italian. PubMed PMID: 1508343.

8: Locatelli A, Ceriana P, Maurelli M, Bertollo D, Bianchi T, Mazza MP, Chiaudani G, Pagnin A. Aprotinin in cardiac surgery. Lancet. 1991 Jul 27;338(8761):254. PubMed PMID: 1712418.

9: Ceriana P, Bertollo D, Bianchi T, Chiaudani G, Locatelli A, Maurelli M, Mazza MP, Pagnin A. [5 years of heart transplants: analysis of the anesthesiologic problems]. Minerva Anestesiol. 1990 Sep;56(9):987-9. Italian. PubMed PMID: 2274242.

10: Bertollo D, Bianchi T, Ceriana P, Chiaudani G, Locatelli A, Maurelli M, Pagnin A, Bosoni T, Goggi D, Pirolini L. [Preliminary study of the preoperative nutritional status and postoperative complications in cardiosurgery]. Minerva Anestesiol. 1990 Sep;56(9):977-8. Italian. PubMed PMID: 2274239.