RPF151

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MedKoo CAT#: 123113

CAS#: N/A

Description: RFP151 is a new capsaicin-like analogue. RPF151 downregulated p21 and cyclins A, D1, and D3, leading to S-phase arrest and apoptosis. Although RPF151 has induced the activation of TRPV-1 and TRAIL-R1/DR4 and TRAIL-2/DR5 on the surface of MDA-MB-231 cells, its in vivo antitumor activity was TRPV-1-independent, thus suggesting that RPF151 should not have the same pungency-based limitation of capsaicin. In silico analysis corroborated the biological findings, showing that RPF151 has physicochemical improvements over capsaicin. Overall, the activity of RPF151 against MDA-MB-231 and its lower pungency suggest that it may have a relevant role in cancer therapy.

Chemical Structure

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RPF151
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 123113
Name: RPF151
CAS#: N/A
Chemical Formula: C12H17NO4S
Exact Mass: 271.09
Molecular Weight: 271.330
Elemental Analysis: C, 53.12; H, 6.32; N, 5.16; O, 23.59; S, 11.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: RPF151; RPF-151; RPF 151

IUPAC/Chemical Name: N-(benzo[d][1,3]dioxol-5-ylmethyl)butane-1-sulfonamide

InChi Key: KREHHXQCESWPEP-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H17NO4S/c1-2-3-6-18(14,15)13-8-10-4-5-11-12(7-10)17-9-16-11/h4-5,7,13H,2-3,6,8-9H2,1H3

SMILES Code: O=S(NCC1=CC=C2C(OCO2)=C1)(CCCC)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 271.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Ferreira AK, Tavares MT, Pasqualoto KF, de Azevedo RA, Teixeira SF, Ferreira-Junior WA, Bertin AM, de-Sá-Junior PL, Barbuto JA, Figueiredo CR, Cury Y, Damião MC, Parise-Filho R. RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model. Tumour Biol. 2015 Sep;36(9):7251-67. doi: 10.1007/s13277-015-3441-z. Epub 2015 Apr 20. PMID: 25894379.