DBCO-sulfo-SE | CAS#N/A | NMOF modification

DBCO-sulfo-SE
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130323

CAS#: N/A

Description: DBCO-sulfo-SE has the potential to be used for the modification of nano-sized metal-organic frameworks (NMOFs) through click chemistry. The NMOFs are able to carry various drugs and fluorescent agents, making them very useful for being able to target and control release drugs.

Chemical Structure

DBCO-sulfo-SE

CAS# N/A

Instruction

Theoretical Analysis

MedKoo Cat#: 130323
Name: DBCO-sulfo-SE
CAS#: N/A
Chemical Formula: C25H21N2NaO8S
Exact Mass: 532.09
Molecular Weight: 532.499
Elemental Analysis: C, 56.39; H, 3.98; N, 5.26; Na, 4.32; O, 24.04; S, 6.02

Price and Availability

Size	Price	Availability
1mg	USD 295	2 Weeks
5mg	USD 600	2 Weeks
50mg	USD 1115	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: DBCO-sulfo-SE; DBCO-sulfo-NHS ester; Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester

IUPAC/Chemical Name: Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester

InChi Key: QXKHPYSXPCJSPR-UHFFFAOYSA-M

InChi Code: InChI=1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1

SMILES Code: O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCCCC(ON(C4=O)C(CC4S(=O)(O[Na])=O)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 532.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201702102

2. Aleman Garcia MA, Hu Y, Willner I. Switchable supramolecular catalysis using DNA-templated scaffolds. Chem Commun (Camb). 2016 Feb 4;52(10):2153-6. doi: 10.1039/c5cc08873a. PMID: 26701068.

3. Zupkauskas M, Lan Y, Joshi D, Ruff Z, Eiser E. Optically transparent dense colloidal gels. Chem Sci. 2017 Aug 1;8(8):5559-5566. doi: 10.1039/c7sc00901a. Epub 2017 May 26. PMID: 28970935; PMCID: PMC5618774.

4. Lee HJ, Fernandes-Cunha GM, Na KS, Hull SM, Myung D. Bio-Orthogonally Crosslinked, In Situ Forming Corneal Stromal Tissue Substitute. Adv Healthc Mater. 2018 Oct;7(19):e1800560. doi: 10.1002/adhm.201800560. Epub 2018 Aug 14. PMID: 30106514; PMCID: PMC6417806.

5. Zhu L, Zhou J, Xu G, Li C, Ling P, Liu B, Ju H, Lei J. DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission. Chem Sci. 2018 Jan 29;9(9):2559-2566. doi: 10.1039/c8sc00001h. PMID: 29732135; PMCID: PMC5911820.

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